Sugi Predict

Sugi Predict / Compounds / SCHEMBL10477404

SCHEMBL10477404

SCHEMBL10477404

Cc1cccc(C)c1C[C@H](NC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ACE P12821 1/20 0.56
▸ PPARA Q07869 6/20 0.51
▸ PPARG P37231 5/20 0.51
▸ ITGB3 P05106 2/20 0.50
▸ ITGA2B P08514 2/20 0.50
▸ PPARD Q03181 2/20 0.49
▸ CTSS P25774 8/20 0.49
▸ CTSK P43235 6/20 0.49
▸ CTSB P07858 3/20 0.49
▸ CTSL P07711 1/20 0.49
▸ IDO1 P14902 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ ITGB1 P05556 1/20 0.47
▸ ITGAV P06756 1/20 0.47
▸ ITGB5 P18084 1/20 0.47
▸ PTPN1 P18031 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12961548 0.88 KLK5 (0.51) ACEPPARAPPARGCTSSCTSK
SCHEMBL10604860 0.86 ACE (0.53) ACEPPARAPPARGITGB3ITGA2B
SCHEMBL2890189 0.86 ACE (0.53) ACEPPARAPPARGITGB3ITGA2B
SCHEMBL19329718 0.85 CTSS (0.54) ACEPPARAPPARGITGB3ITGA2B
SCHEMBL19329712 0.85 CTSS (0.54) ACEPPARAPPARGITGB3ITGA2B
SCHEMBL1529787 0.85 PTPN1 (0.55) ACEPPARAPPARGITGB3ITGA2B
SCHEMBL269930 0.85 ACE (0.58) ACEPPARAPPARGITGB3ITGA2B
SCHEMBL873556 0.85 ACE (0.58) ACEPPARAPPARGITGB3ITGA2B
SCHEMBL269929 0.85 ACE (0.58) ACEPPARAPPARGITGB3ITGA2B
SCHEMBL4584520 0.85 PTPN1 (0.55) ACEPPARAPPARGITGB3ITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11795196-B2 Mitochondria-targeting peptides STEALTH BIOTHERAPEUTICS INC. (US) 2023-10-24 — — US disclosed
US-20230279052-A1 PRODRUGS OF MITOCHONDRIA-TARGETING OLIGOPEPTIDES STEALTH BIOTHERAPEUTICS INC. 2023-09-07 — — US disclosed
EP-4218785-A2 MITOCHONDRIA-TARGETING PEPTIDES Stealth BioTherapeutics Inc. (US) 2023-08-02 — — EP disclosed
US-20230227499-A1 PRODRUGS OF MITOCHONDRIA-TARGETING OLIGOPEPTIDES STEALTH BIOTHERAPEUTICS INC. 2023-07-20 — — US disclosed
US-20230146515-A1 MITOCHONDRIA-TARGETING PEPTIDES STEALTH BIOTHERAPEUTICS INC. 2023-05-11 — — US disclosed
WO-2023069549-A1 METHODS AND COMPOSITIONS COMPRISING PEPTIDOMIMITICS FOR TREATING, PREVENTING, INHIBITING, AMELIORATING OR DELAYING THE ONSET OF OPHTHALMIC CONDITIONS STEALTH BIOTHERAPEUTICS INC. (US) 2023-04-27 — — WO disclosed
WO-2023069255-A1 METHODS AND COMPOSITIONS COMPRISING PEPTIDOMIMITICS FOR TREATING, PREVENTING, INHIBITING, AMELIORATING OR DELAYING THE ONSET OF OPHTHALMIC CONDITIONS STEALTH BIOTHERAPEUTICS INC. (US) 2023-04-27 — — WO disclosed
EP-3723783-B1 MITOCHONDRIA-TARGETING PEPTIDES STEALTH BIOTHERAPEUTICS INC (US) 2023-02-15 — — EP disclosed
US-11273149-B2 Compositions and methods for the treatment of amyotrophic lateral sclerosis, Parkinson's disease, Parkinson's disease with dementia, dementia with Lewy bodies, and multiple system atrophy STEALTH BIOTHERAPEUTICS INC. (US) 2022-03-15 — — US disclosed
WO-2021262710-A1 PRODRUGS OF MITOCHODRIA-TARGETING OLIGOPEPTIDES STEALTH BIOTHERAPEUTICS CORP. (KY) 2021-12-30 — — WO disclosed
WO-2021262708-A1 PRODRUGS OF MITOCHODRIA-TARGETING OLIGOPEPTIDES STEALTH BIOTHERAPEUTICS CORP. (KY) 2021-12-30 — — WO disclosed
US-20210023062-A1 Compositions and Methods for the Treatment of Amyotrophic Lateral Sclerosis, Parkinson's Disease, Parkinson's Disease with Dementia, Dementia with Lewy Bodies, and Multiple System Atrophy STEALTH BIOTHERAPEUTICS INC. 2021-01-28 — — US disclosed
WO-2021016462-A1 THE PEPTIDOMIMETIC COMPOUND (R)-2-AMINO-N-((S)-L-(((S)-5-AMINO-L-(3-BENZYL-1,2,4-OXADIAZOL-5-YL)PENTYL)AMINO)-3-(4-HYDROXY-2,6-DIMETHYLPHENYL)-I-OXOPROPAN-2-YL)-5-GUANIDINOPENTANAMIDE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES STEALTH BIOTHERAPEUTICS CORP (MC) 2021-01-28 — — WO disclosed
WO-2019118878-A1 MITOCHONDRIA-TARGETING PEPTIDES STEALTH BIOTHERAPEUTICS CORP. (MC) 2019-06-20 — — WO disclosed
US-4879398-A Process for producing 2,6-disubstituted tyrosine MONSANTO COMPANY (US) 1989-11-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230227499-A1 PRODRUGS OF MITOCHONDRIA-TARGETING OLIGOPEPTIDES PITRM1, NME4, PDF ACE 2514/4885PPARA 737/4885PPARG 776/4885
US-20230279052-A1 PRODRUGS OF MITOCHONDRIA-TARGETING OLIGOPEPTIDES ARG2, NLN, OAT ACE 3286/4885PPARA 1070/4885PPARG 1164/4885
US-11795196-B2 Mitochondria-targeting peptides HSPE1, TFAM, TNNI3 ACE 4361/4885PPARA 1208/4885PPARG 1157/4885
US-11273149-B2 Compositions and methods for the treatment of amyotrophic lateral sclerosis, Parkinson's disease, Parkinson's disease with dementia, dementia with Lewy bodies, and multiple system atrophy NLN, TARDBP, PARK7 ACE 3713/4885PPARA 797/4885PPARG 1418/4885
US-20210023062-A1 Compositions and Methods for the Treatment of Amyotrophic Lateral Sclerosis, Parkinson's Disease, Parkinson's Disease with Dementia, Dementia with Lewy Bodies, and Multiple System Atrophy NLN, TARDBP, PARK7 ACE 3713/4885PPARA 797/4885PPARG 1418/4885
US-20230146515-A1 MITOCHONDRIA-TARGETING PEPTIDES HSPE1, TFAM, TNNI3 ACE 4361/4885PPARA 1208/4885PPARG 1157/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.