Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566461 | 0.87 | L3MBTL1 (0.49) | ADORA2ATDP2KMT2AMEN1L3MBTL1 | |
| SCHEMBL9566552 | 0.87 | GABRP (0.48) | ADORA1CDK5CDK5R1KMT2AMEN1 | |
| SCHEMBL9566616 | 0.85 | ALDH1A1 (0.46) | KMT2AMEN1JAK2TYK2KDM4E | |
| SCHEMBL9566563 | 0.84 | TYK2 (0.49) | KMT2AMEN1JAK2TYK2SMN1; SMN2 | |
| SCHEMBL10483353 | 0.83 | SIRT2 (0.55) | KMT2AMEN1KDM4EHTT | |
| SCHEMBL9566580 | 0.82 | L3MBTL1 (0.42) | KMT2AL3MBTL1JAK2TYK2LMNA | |
| SCHEMBL10483488 | 0.82 | L3MBTL1 (0.45) | CDK1CDK2KDRCSNK1A1CSNK1D | |
| SCHEMBL9566459 | 0.81 | JAK2 (0.45) | KMT2AMEN1JAK2TYK2SMN1; SMN2 | |
| SCHEMBL9566514 | 0.80 | CSNK1D (0.45) | CSNK1DCSNK1EKDM4ELMNAMAPT | |
| SCHEMBL9566531 | 0.79 | HDAC1 (0.48) | PLAUKMT2AMEN1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | claimed |
| EP-0563386-A1 | ANTICANCER COMPOSITION AND COMPOUND | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-10-06 | — | — | EP | disclosed |
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | disclosed |