Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20988117 | 0.82 | KDM4E (0.40) | PARP1GAASMN1; SMN2ALDH1A1TRPV6 | |
| SCHEMBL178440 | 0.79 | LOXL2 (0.41) | PARP1GAASMN1; SMN2ALDH1A1TRPV6 | |
| SCHEMBL19476289 | 0.76 | PARP1 (0.39) | PARP1GAASMN1; SMN2ALDH1A1TRPV6 | |
| SCHEMBL3271284 | 0.75 | SIGMAR1 (0.48) | PARP1SMN1; SMN2ALDH1A1LMNASLC2A1 | |
| SCHEMBL4827198 | 0.75 | ALDH1A1 (0.40) | GAASMN1; SMN2ALDH1A1TRPV6LMNA | |
| SCHEMBL13772689 | 0.75 | GAA (0.54) | GAASMN1; SMN2ALDH1A1LMNAOPRM1 | |
| SCHEMBL1196047 | 0.73 | KMT2A (0.51) | GAASMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL19954179 | 0.73 | PARP1 (0.45) | PARP1SMN1; SMN2ALDH1A1TRPV6LMNA | |
| SCHEMBL24060739 | 0.72 | GAA (0.41) | GAASMN1; SMN2ALDH1A1TRPV6HIF1A | |
| SCHEMBL313756 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | NR0B1, GRK7, NR5A2 | PARP1 4540/4885GAA 4229/4885SMN1; SMN2 4581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.