Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLN | Q9BYT8 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 4/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 3/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521853 | 0.84 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL10522368 | 0.72 | REN (0.54) | RENFNTAPGGT1B | |
| SCHEMBL10523789 | 0.72 | HRH4 (0.36) | — | |
| SCHEMBL10519909 | 0.71 | KMT2A (0.52) | — | |
| SCHEMBL10520328 | 0.71 | REN (0.54) | NLNRENFNTAFNTBPGGT1B | |
| SCHEMBL11158707 | 0.71 | ITGB2 (0.58) | ALOX5PDCD1CD274FNTAFNTB | |
| SCHEMBL14046801 | 0.71 | L3MBTL1 (0.57) | ALOX5 | |
| SCHEMBL10522976 | 0.70 | ANPEP (0.40) | REN | |
| SCHEMBL10519260 | 0.69 | GAA (0.38) | FNTAFNTB | |
| SCHEMBL7598348 | 0.68 | ITGB2 (0.55) | ALOX5PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |