Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1052822 | 0.78 | — | — | |
| SCHEMBL4454689 | 0.77 | LMNA (0.44) | LMNACYP2C19FDPS | |
| SCHEMBL10952581 | 0.77 | LMNA (0.44) | LMNACYP2C19FDPS | |
| Trimethyl Phosphate SCHEMBL28467805 | 0.74 | GABBR2 (0.41) | LMNACYP2C19GABBR2GABBR1GABRR1 | |
| SCHEMBL5897538 | 0.73 | LMNA (0.41) | LMNACYP2C19GABBR2GABBR1GABRR1 | |
| SCHEMBL4452186 | 0.73 | LMNA (0.41) | LMNACYP2C19FDPS | |
| Phosphoric Acid Monomethyl Ester SCHEMBL28465205 | 0.72 | GABBR2 (0.44) | LMNACYP2C19GABBR2GABBR1GABRR1 | |
| SCHEMBL20664153 | 0.72 | GABBR2 (0.34) | LMNACYP2C19GABBR2GABBR1GABRR1 | |
| SCHEMBL14438178 | 0.71 | LMNA (0.40) | LMNACYP2C19FDPS | |
| SCHEMBL4453650 | 0.70 | LMNA (0.39) | LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198060-B2 | for drug screening; targets for anti-nematode vaccines, pesticides, and drugs | DIVERGENCE, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-7867749-B2 | Nematode phosphoethanolamine N-methyltransferase-like sequences | DIVERGENCE, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-20090318563-A1 | Nematicidal Compositions and Methods | DIVERGENCE, INC. | 2009-12-24 | — | — | US | disclosed |
| US-20090123986-A1 | Nematode Phosphoethanolamine N-Methyltransferase-Like Sequences | DIVERGENCE, INC. | 2009-05-14 | — | — | US | disclosed |
| US-7442533-B2 | Nematode phosphoethanolamine N-methyltransferase-like sequences | DIVERGENCE, INC. (US) | 2008-10-28 | — | — | US | disclosed |
| US-20070009981-A1 | Nematode phosphoethanolamine N-methyltransferase-like sequences | MONSANTO TECHNOLOGY LLC | 2007-01-11 | — | — | US | disclosed |
| EP-1578929-A4 | NEMATODE PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE-LIKE SEQUENCES | DIVERGENCE INC (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2006060654-A2 | PESTICIDAL COMPOSITIONS AND METHODS | DIVERGENCE, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| EP-1578929-A2 | NEMATODE PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE-LIKE SEQUENCES | Divergence, Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050203067-A1 | Pesticidal compositions and methods | DIVERGENCE, INC. | 2005-09-15 | — | — | US | disclosed |
| US-20040254150-A1 | Nematicidal compositions and methods | DIVERGENCE, INC. | 2004-12-16 | — | — | US | disclosed |
| WO-2004103070-A2 | NEMATICIDAL COMPOSITIONS AND METHODS | DIVERGENCE, INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| US-20040091467-A1 | Nematode phosphoethanolamine n-methyltransferase-like sequences | MONSANTO TECHNOLOGY LLC | 2004-05-13 | — | — | US | disclosed |
| WO-2004001011-A2 | NEMATODE PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE-LIKE SEQUENCES | DIVERGENCE, INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254150-A1 | Nematicidal compositions and methods | NISCH, PNMT, ATL3 | LMNA 811/4885CYP2C19 3432/4885GABBR2 1586/4885 |
| US-20070009981-A1 | Nematode phosphoethanolamine N-methyltransferase-like sequences | PNMT, HNMT, GNMT | LMNA 3432/4885CYP2C19 4879/4885GABBR2 4838/4885 |
| US-20040091467-A1 | Nematode phosphoethanolamine n-methyltransferase-like sequences | PNMT, HNMT, GNMT | LMNA 3432/4885CYP2C19 4879/4885GABBR2 4838/4885 |
| US-20050203067-A1 | Pesticidal compositions and methods | ACHE, DDT, PTMS | LMNA 1278/4885CYP2C19 1327/4885GABBR2 568/4885 |
| US-20090318563-A1 | Nematicidal Compositions and Methods | NISCH, PNMT, HNMT | LMNA 942/4885CYP2C19 3278/4885GABBR2 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.