Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 5/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714132 | 0.87 | GAA (0.40) | PDE7APDE4ACYP11B1CYP11B2STIM1 | |
| SCHEMBL9714161 | 0.80 | CA5A (0.48) | PDE7APDE4ACYP11B1CYP11B2CA5A | |
| SCHEMBL10564954 | 0.77 | CYP11B2 (0.48) | CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL10773961 | 0.72 | ROCK2 (0.37) | PDE7APDE4ACYP11B1CYP11B2CA5A | |
| SCHEMBL9714339 | 0.72 | RIPK1 (0.41) | PDE7APDE4ACA5AKLKB1 | |
| SCHEMBL9857936 | 0.69 | CA5A (0.66) | CA5AKLKB1ALDH1A1 | |
| SCHEMBL9714409 | 0.66 | AURKA (0.40) | CA5AGPBAR1 | |
| SCHEMBL13328951 | 0.65 | CES2 (0.52) | ALDH1A1 | |
| SCHEMBL10569749 | 0.64 | CYP11B2 (0.46) | CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL9733613 | 0.64 | GRK2 (0.36) | CA5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |