Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734773 | 0.88 | GAA (0.41) | GRK2ROCK2TP53KMT2AHDAC6 | |
| SCHEMBL9734745 | 0.85 | BRD4 (0.39) | GRK2ROCK2TP53HDAC6L3MBTL1 | |
| SCHEMBL9735004 | 0.81 | CA5A (0.44) | GRK2ROCK2TP53ALDH1A1CA5A | |
| SCHEMBL9733899 | 0.77 | ALDH1A1 (0.42) | KMT2AMEN1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL9734947 | 0.73 | ALDH1A1 (0.38) | GRK2ROCK2TP53ALDH1A1NPC1 | |
| SCHEMBL9733514 | 0.68 | CA5A (0.42) | TP53KMT2AMEN1ALDH1A1CA5A | |
| SCHEMBL9733462 | 0.68 | GAA (0.48) | KMT2AMEN1PKMALDH1A1NPC1 | |
| SCHEMBL9857936 | 0.67 | CA5A (0.66) | KMT2AMEN1ALDH1A1LMNACA5A | |
| SCHEMBL9734269 | 0.66 | ALDH1A1 (0.41) | TP53KMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL13328951 | 0.65 | CES2 (0.52) | KMT2AMEN1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098922-A | Anticonvulsants | CIBA-GEIGY CORPORATION (US) | 1992-03-24 | — | — | US | claimed |
| US-5045556-A | Aralkyl-4H-1,2,4-triazole derivatives | CIBA-GEIGY CORPORATION (US) | 1991-09-03 | — | — | US | claimed |
| EP-0267147-B1 | ARALKYL-4H-1,2,4-TRIAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1991-08-07 | — | — | EP | claimed |
| EP-0267147-A1 | Aralkyl-4H-1,2,4-triazole derivatives | CIBA-GEIGY AG (CH) | 1988-05-11 | — | — | EP | claimed |
| US-5098922-A | Anticonvulsants | CIBA-GEIGY CORPORATION (US) | 1992-03-24 | — | — | US | disclosed |
| US-5045556-A | Aralkyl-4H-1,2,4-triazole derivatives | CIBA-GEIGY CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |
| EP-0267147-B1 | ARALKYL-4H-1,2,4-TRIAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1991-08-07 | — | — | EP | disclosed |
| EP-0267147-A1 | Aralkyl-4H-1,2,4-triazole derivatives | CIBA-GEIGY AG (CH) | 1988-05-11 | — | — | EP | disclosed |