Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574083 | 0.92 | LOXL2 (0.39) | DGAT1KCNH2SOAT1KDM4EALDH1A1 | |
| SCHEMBL10579971 | 0.87 | NPC1 (0.49) | DGAT1KCNH2SOAT1KDM4EALDH1A1 | |
| SCHEMBL10574922 | 0.86 | HDAC6 (0.43) | DGAT1KCNH2SOAT1KDM4EALDH1A1 | |
| SCHEMBL10574279 | 0.86 | SLC2A1 (0.55) | KDM4EALDH1A1POLBMAPTHPGD | |
| SCHEMBL10576087 | 0.84 | ALOX5 (0.56) | KDM4EALDH1A1HPGDTRPV1CHEK2 | |
| SCHEMBL10574680 | 0.82 | NPBWR1 (0.59) | DGAT1KCNH2SOAT1ALDH1A1MAPT | |
| SCHEMBL10578447 | 0.82 | NPBWR1 (0.40) | DGAT1KCNH2SOAT1KDM4EALDH1A1 | |
| SCHEMBL10576002 | 0.82 | HDAC6 (0.36) | DGAT1KCNH2MAPTTRPV1HRH4 | |
| SCHEMBL10578004 | 0.81 | NPBWR1 (0.58) | DGAT1KCNH2SOAT1TRPV1NPBWR1 | |
| SCHEMBL10577338 | 0.81 | DGAT1 (0.57) | DGAT1KCNH2SOAT1MAPTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |