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SCHEMBL10581344

SCHEMBL10581344

NC(=O)CNC(=O)CN1CC(OCc2ccccc2)=CC1=O

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SPHK2 Q9NRA0 2/20 0.43
▸ SPHK1 Q9NYA1 1/20 0.40
▸ OPRM1 P35372 9/20 0.38
▸ OPRL1 P41146 9/20 0.38
▸ HTT P42858 1/20 0.38
▸ PARP10 Q53GL7 1/20 0.36
▸ LTA4H P09960 1/20 0.36
▸ HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10350819 0.87 HTT (0.43) SPHK2SPHK1HTTPARP10
SCHEMBL10484199 0.81 KMT2A (0.46) HTTPARP10
SCHEMBL10351261 0.78 ALDH1A1 (0.45) HTT
SCHEMBL10583879 0.67 ALDH1A1 (0.43) HPGD
SCHEMBL8156969 0.66 ALDH1A1 (0.58) HTT
SCHEMBL16258192 0.66 ALDH1A1 (0.58) HTT
SCHEMBL7769258 0.65 KMT2A (0.57) HPGD
SCHEMBL2820683 0.64 LMNA (0.61) SPHK2HTT
SCHEMBL5485588 0.64 LMNA (0.61) SPHK2HTT
SCHEMBL9821188 0.64 TP53 (0.67) HTTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0301398-A2 Process for producing N-[(4-hydroxy-pyrrolidin-2-on-1-yl)-acetyl]-glycinamide LONZA AG (CH) 1989-02-01 — — EP claimed
EP-0301398-A2 Process for producing N-[(4-hydroxy-pyrrolidin-2-on-1-yl)-acetyl]-glycinamide LONZA AG (CH) 1989-02-01 — — EP disclosed
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