Water

Water

SCHEMBL1065337

Nc1ccc(-c2ccc(N)c(N)c2)cc1N.O

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 4/20 0.93
THRB known ✓ P10828 1/20 0.48
ESR2 known ✓ Q92731 1/20 0.41
TDP1 Q9NUW8 6/20 0.93
KMT2A Q03164 5/20 0.93
KCNH2 Q12809 2/20 0.58
CYP3A4 P08684 8/20 0.52
ALDH1A1 P00352 7/20 0.52
ALOX15 P16050 6/20 0.52
HSD17B10 Q99714 5/20 0.52
TSHR P16473 4/20 0.52
CYP17A1 P05093 2/20 0.50
CYP19A1 P11511 2/20 0.50
CYP11B1 P15538 2/20 0.50
CYP11B2 P19099 2/20 0.50
MAPK1 P28482 2/20 0.50
SMN1; SMN2 Q16637 3/20 0.48
TP53 P04637 1/20 0.48
NR4A1 P22736 1/20 0.46
KDM4E B2RXH2 4/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL10589317 1.00 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4
Water SCHEMBL3137651 1.00 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL6650565 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL30078382 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL866164 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL28836366 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4
SCHEMBL23855 0.97 TDP1 (1.00) TDP1KMT2AMEN1KCNH2CYP3A4
SCHEMBL29349835 0.97 TDP1 (1.00) TDP1KMT2AMEN1KCNH2CYP3A4
SCHEMBL8745318 0.93 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4
Methane SCHEMBL1599658 0.93 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11597694-B2 Method for producing lactic acid and method for producing polylactic acid TORAY INDUSTRIES, INC. (JP) 2023-03-07 US disclosed
US-20200325097-A1 METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID TORAY INDUSTRIES, INC. (JP) 2020-10-15 US disclosed
US-10683254-B2 Method for producing lactic acid and method for producing polylactic acid TORAY INDUSTRIES, INC. (JP) 2020-06-16 US disclosed
EP-3147275-B1 METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID TORAY INDUSTRIES (JP) 2019-10-23 EP disclosed
EP-2840150-B1 Method for producing sugar liquid TORAY INDUSTRIES (JP) 2019-10-16 EP disclosed
US-20180291151-A1 Functionalized Polyamides And Methods Of Preparing The Same FIRESTONE FIBERS & TEXTILES COMPANY, LLC 2018-10-11 US disclosed
US-10093747-B2 Method for production sugar liquid TORAY INDUSTRIES, INC. (JP) 2018-10-09 US disclosed
EP-3147275-A1 METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID TORAY INDUSTRIES, INC. (JP) 2017-03-29 EP disclosed
EP-2263996-B1 PROCESS FOR PRODUCING DIAMINE AND POLYAMIDE TORAY INDUSTRIES (JP) 2016-09-14 EP disclosed
EP-2692872-B1 METHOD FOR MANUFACTURING SUGAR SOLUTION TORAY INDUSTRIES (JP) 2015-12-30 EP disclosed
US-8334411-B2 Process for producing diamine and polyamide TORAY INDUSTRIES, INC. (JP) 2012-12-18 US disclosed
US-20110263811-A1 METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID TORAY INDUSTRIES, INC. (JP) 2011-10-27 US disclosed
US-20110250637-A1 METHOD FOR PRODUCING SUGAR LIQUID TORAY INDUSTRIES, INC. (JP) 2011-10-13 US disclosed
EP-2374895-A1 METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID Toray Industries, Inc. (JP) 2011-10-12 EP disclosed
EP-2371973-A1 METHOD FOR PRODUCING SUGAR LIQUID Toray Industries, Inc. (JP) 2011-10-05 EP disclosed
US-20110004018-A1 PROCESS FOR PRODUCING DIAMINE AND POLYAMIDE TORAY INDUSTRIES, INC. (JP) 2011-01-06 US disclosed
EP-2263996-A1 PROCESS FOR PRODUCING DIAMINE AND POLYAMIDE Toray Industries, Inc. (JP) 2010-12-22 EP disclosed
US-20100190222-A1 LACTIC ACID PRODUCTION METHOD TORAY INDUSTRIES, INC. (JP) 2010-07-29 US disclosed
EP-2175029-A1 LACTIC ACID PRODUCTION METHOD Toray Industries, Inc. (JP) 2010-04-14 EP disclosed
EP-0538850-B1 New polyurea resins and their preparation and use IHARA CHEMICAL IND CO (JP) 1997-01-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263811-A1 METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID MLEC, FIBP, LDHA MEN1 1090/4885THRB 4591/4885ESR2 4843/4885
US-11597694-B2 Method for producing lactic acid and method for producing polylactic acid MLEC, FIBP, LDHA MEN1 1090/4885THRB 4591/4885ESR2 4843/4885
US-10683254-B2 Method for producing lactic acid and method for producing polylactic acid MLEC, FIBP, LDHA MEN1 1090/4885THRB 4591/4885ESR2 4843/4885
US-20110004018-A1 PROCESS FOR PRODUCING DIAMINE AND POLYAMIDE NAAA, PUF60, DNPEP MEN1 1022/4885THRB 4383/4885ESR2 4800/4885
US-20200325097-A1 METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID MLEC, FIBP, LDHA MEN1 1090/4885THRB 4591/4885ESR2 4843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.