Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692186 | 0.97 | BACE1 (0.35) | BACE1L3MBTL1GAAHSD17B10GRIN1 | |
| SCHEMBL10692789 | 0.89 | BACE1 (0.37) | BACE1GAAHSD17B10BACE2LMNA | |
| SCHEMBL10694802 | 0.84 | BACE1 (0.44) | BACE1BACE2TSHRALDH1A1 | |
| SCHEMBL10694665 | 0.81 | RAD52 (0.36) | HSD17B10LMNAHTTTSHRALDH1A1 | |
| SCHEMBL10693819 | 0.77 | OPRD1 (0.40) | — | |
| SCHEMBL10696619 | 0.77 | RAD52 (0.34) | HSD17B10HTTALDH1A1DRD2 | |
| SCHEMBL10691593 | 0.74 | L3MBTL1 (0.42) | BACE1L3MBTL1BACE2LMNATSHR | |
| SCHEMBL10691351 | 0.71 | GPR55 (0.39) | GAAHSD17B10LMNAHTTTSHR | |
| SCHEMBL10674089 | 0.68 | BACE1 (0.37) | BACE1L3MBTL1GAAHSD17B10BACE2 | |
| SCHEMBL10691597 | 0.67 | ADRA1A (0.39) | L3MBTL1GAATSHRALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |