Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.35 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10711888 | 0.83 | BRD4 (0.40) | EDNRBEDNRACREBBPBRD4ALDH1A1 | |
| SCHEMBL10712822 | 0.81 | ALDH1A1 (0.40) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL10714044 | 0.78 | TRPM2 (0.38) | PGRCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL117727 | 0.78 | CACNB4 (0.40) | PGRCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL10711932 | 0.77 | HDAC4 (0.40) | EDNRBEDNRACREBBPBRD4ALDH1A1 | |
| SCHEMBL10712632 | 0.75 | PGR (0.39) | PGRCYP1A2MAPTCYP2C19HTR7 | |
| SCHEMBL10712953 | 0.75 | IDO1 (0.35) | BRD4ALDH1A1CYP1A2MAPTCYP2C9 | |
| SCHEMBL10714048 | 0.75 | ALDH1A1 (0.36) | ALDH1A1CYP1A2MAPTHPGD | |
| SCHEMBL11368672 | 0.73 | DAO (0.40) | CREBBPALDH1A1MAPTAGTR1GSK3B | |
| SCHEMBL10711944 | 0.73 | CREBBP (0.46) | EDNRBEDNRACREBBPPTPRCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |