Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 5/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CTSE | P14091 | 1/20 | 0.42 |
| ▸ | PGC | P20142 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 3/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716075 | 1.00 | LTA4H (0.46) | LTA4HPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7286416 | 0.84 | LTA4H (0.47) | LTA4HPSMB5MMP2CTSDCTSE | |
| SCHEMBL7286409 | 0.84 | LTA4H (0.47) | LTA4HPSMB5MMP2CTSDCTSE | |
| Hydrochloric Acid SCHEMBL10718561 | 0.82 | ACE2 (0.48) | PSMB5MMP2CTSDANPEPERAP2 | |
| SCHEMBL10718807 | 0.79 | CPB2 (0.48) | — | |
| SCHEMBL7308131 | 0.74 | CTSD (0.45) | LTA4HPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7296156 | 0.73 | REN (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL9848349 | 0.73 | CTSD (0.55) | RENCTSDCTSEPGC | |
| Hydrochloric Acid SCHEMBL9848368 | 0.73 | CTSD (0.55) | RENCTSDCTSEPGC | |
| SCHEMBL7308139 | 0.72 | MMP1 (0.42) | LTA4HRENMMP2ANPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209848-A2 | Enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0209848-A2 | Enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |