Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | CTSE | P14091 | 1/20 | 0.45 |
| ▸ | PGC | P20142 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 11/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296156 | 0.83 | REN (0.49) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7306963 | 0.80 | CPB2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL9848368 | 0.77 | CTSD (0.55) | CTSDCTSEPGCRENBACE1 | |
| Hydrochloric Acid SCHEMBL9848349 | 0.77 | CTSD (0.55) | CTSDCTSEPGCRENBACE1 | |
| SCHEMBL7286409 | 0.77 | LTA4H (0.47) | CTSDCTSEPGCLTA4HMME | |
| SCHEMBL7286416 | 0.77 | LTA4H (0.47) | CTSDCTSEPGCLTA4HMME | |
| SCHEMBL7308139 | 0.75 | MMP1 (0.42) | RENLTA4HMMEACECPA1 | |
| SCHEMBL10716078 | 0.74 | LTA4H (0.46) | CTSDCTSEPGCRENLTA4H | |
| SCHEMBL10716075 | 0.74 | LTA4H (0.46) | CTSDCTSEPGCRENLTA4H | |
| Hydrochloric Acid SCHEMBL8535563 | 0.74 | CTSD (0.52) | CTSDCTSEPGCRENBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | claimed |