SCHEMBL1083281

SCHEMBL1083281

O=C(OC(=O)C(Cl)Cl)OC(=O)C(Cl)Cl

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
SOAT1 P35610 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL187025 0.86 LMNA (0.44) LMNA
SCHEMBL8523741 0.80 LMNA (0.39) LMNA
SCHEMBL187026 0.75
SCHEMBL4154811 0.75 TSHR (0.35) SOAT1
SCHEMBL9781203 0.75
SCHEMBL4645074 0.75
SCHEMBL8586196 0.73 ALDH1A1 (0.36) LMNA
SCHEMBL20302569 0.73 ALDH1A1 (0.38) LMNA
SCHEMBL7509907 0.72 LMNA (0.44) LMNA
SCHEMBL11325929 0.71 TSHR (0.32) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11957760-B2 Folate receptor targeted nanoparticle drug conjugates and uses thereof ELUCIDA ONCOLOGY, INC. (US) 2024-04-16 US disclosed
EP-4275758-A2 METHODS OF FUNCTIONALIZING NANOPARTICLES Elucida Oncology, Inc. (US) 2023-11-15 EP disclosed
EP-4257156-A2 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF Elucida Oncology, Inc. (US) 2023-10-11 EP disclosed
WO-2023178299-A1 PRODRUGS OF GANAXOLONE MARINUS PHARMACEUTICALS, INC. (US) 2023-09-21 WO disclosed
EP-4237008-A2 CARRIER PARTICLE-DRUG CONJUGATES, SELF-IMMOLATIVE LINKERS, AND USES THEREOF Elucida Oncology, Inc. (US) 2023-09-06 EP disclosed
US-11744897-B2 Folate receptor targeted nanoparticle drug conjugates and uses thereof ELUCIDA ONCOLOGY, INC. (US) 2023-09-05 US disclosed
US-20230263899-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF ELUCIDA ONCOLOGY, INC. 2023-08-24 US disclosed
US-20230263898-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF ELUCIDA ONCOLOGY, INC. 2023-08-24 US disclosed
EP-4106820-B1 METHODS OF FUNCTIONALIZING NANOPARTICLES ELUCIDA ONCOLOGY INC (US) 2023-08-16 EP disclosed
EP-4103236-B1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF ELUCIDA ONCOLOGY INC (US) 2023-08-16 EP disclosed
US-8772335-B2 Adamantyl derivatives as therapeutic agents WOMAN & INFANTS' HOSPITAL OF RHODE ISLAND (US) 2014-07-08 US disclosed
US-20140121186-A1 Compounds, Compositions and Methods for Treating Ocular Conditions CHIMERIX, INC. (US) 2014-05-01 US disclosed
US-8614200-B2 Compounds, compositions and methods for treating ocular conditions CHIMERIX, INC. (US) 2013-12-24 US disclosed
US-20130143962-A1 Adamantyl Derivatives as Therapeutic Agents WOMEN & INFANTS' HOSPITAL OF RHODE ISLAND (US) 2013-06-06 US disclosed
US-20120165295-A1 Compounds, Compositions and Methods for Treating Ocular Conditions CHIMERIX, INC. (US) 2012-06-28 US disclosed
WO-2012074980-A2 METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISORDERS AND LIVER DISORDERS USING INDANE ACETIC ACID DERIVATIVES DARA BIOSCIENCES, INC. (US) 2012-06-07 WO disclosed
WO-2011011519-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OCULAR CONDITIONS CHIMERIX, INC. (US) 2011-01-27 WO disclosed
WO-2010141690-A2 INDANE ANALOGS AND USE AS PHARMACEUTICAL AGENTS AND PROCESS OF MAKING DARA BIOSCIENCES, INC. (US) 2010-12-09 WO disclosed
US-20100297079-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTION CHIMERIX, INC. (US) 2010-11-25 US disclosed
WO-2010135520-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTION CHIMERIX, INC. (US) 2010-11-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140121186-A1 Compounds, Compositions and Methods for Treating Ocular Conditions EYA3, EYA2, PDE6C LMNA 2085/4885SOAT1 1213/4885
US-11957760-B2 Folate receptor targeted nanoparticle drug conjugates and uses thereof FOLR1, FOLR2, DHFR LMNA 3136/4885SOAT1 2652/4885
US-20230263899-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF FOLR1, FOLR2, DHFR LMNA 3136/4885SOAT1 2652/4885
US-20120165295-A1 Compounds, Compositions and Methods for Treating Ocular Conditions EYA3, EYA2, PDE6C LMNA 2085/4885SOAT1 1213/4885
US-20130143962-A1 Adamantyl Derivatives as Therapeutic Agents MCL1, TOP2A, TP53 LMNA 2593/4885SOAT1 2189/4885
US-20100297079-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTION HAVCR2, EIF2AK2, OAT LMNA 1914/4885SOAT1 1354/4885
US-20230263898-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF FOLR1, FOLR2, DHFR LMNA 3136/4885SOAT1 2652/4885
US-11744897-B2 Folate receptor targeted nanoparticle drug conjugates and uses thereof FOLR1, FOLR2, DHFR LMNA 3136/4885SOAT1 2652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.