Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.44 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.30 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091791 | 0.89 | THRB (0.52) | TSHRRECQLGLAHPGDMAPK1 | |
| SCHEMBL19463944 | 0.88 | TSHR (0.69) | TSHRRECQLGLAHPGDMAPK1 | |
| Lithium Ion SCHEMBL17456573 | 0.86 | THRB (0.52) | TSHRRECQLGLAHPGDMAPK1 | |
| SCHEMBL5969177 | 0.82 | TSHR (0.55) | TSHRHPGDTHRBPOLBAPEX1 | |
| SCHEMBL182045 | 0.81 | TSHR (0.72) | TSHRHPGDTHRBPOLBAPEX1 | |
| SCHEMBL345585 | 0.81 | TSHR (0.53) | TSHRMAPK1EPHX2THRBPOLB | |
| SCHEMBL17704110 | 0.79 | TSHR (0.51) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL8746515 | 0.79 | TSHR (0.56) | TSHRRECQLGLAHPGDMAPK1 | |
| SCHEMBL9162964 | 0.79 | TSHR (0.69) | TSHRHPGDTHRBPOLBAPEX1 | |
| SCHEMBL11600594 | 0.79 | TSHR (0.69) | TSHRHPGDTHRBPOLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0089812-B1 | N-SUBSTITUTED PSEUDO-AMINOSUGARS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1986-10-01 | — | — | EP | claimed |
| EP-0095920-B1 | A COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1986-11-26 | — | — | EP | disclosed |
| US-4587208-A | SILVER HALIDE EMULSIONS WITH ULTRAVIOLET RADIATION ABSORBERS | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1986-05-06 | — | — | US | disclosed |
| EP-0095920-A2 | A color photographic light-sensitive material | KONICA CORPORATION (JP) | 1983-12-07 | — | — | EP | disclosed |