Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 4/20 | 0.47 |
| ▸ | KDM4A | O75164 | 4/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.47 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.47 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10734964 | 0.94 | KDM6B (0.46) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL11421113 | 0.82 | KDM6B (0.53) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL10733027 | 0.81 | LMNA (0.58) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL10655643 | 0.77 | LMNA (0.60) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL10622845 | 0.73 | PLA2G7 (0.56) | LMNAPLA2G7DAO | |
| SCHEMBL31087177 | 0.72 | ALDH1A1 (0.65) | LMNAALDH1A1HTTKDM4E | |
| SCHEMBL7708557 | 0.72 | PLA2G7 (0.64) | LMNAPLA2G7 | |
| SCHEMBL16580714 | 0.72 | KDM4E (0.61) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL11002242 | 0.70 | L3MBTL1 (0.50) | LMNAALDH1A1HTTKDM4E | |
| SCHEMBL10652674 | 0.70 | PLA2G7 (0.62) | KDM6BKDM4AKDM4DHIF1ANKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4524071-A | HISTAMINE H2-ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1985-06-18 | — | — | US | disclosed |