Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017639 | 0.93 | MAPT (0.49) | ALDH1A1MAPTPKMUSP2POLB | |
| SCHEMBL11018071 | 0.88 | CYP2C9 (0.47) | SCN9AMAPK10CA12CA1CA2 | |
| SCHEMBL11016112 | 0.88 | SCN9A (0.42) | ALDH1A1MAPTLMNAHTTSCN9A | |
| SCHEMBL10763275 | 0.86 | MAPK10 (0.42) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11021893 | 0.84 | ATR (0.44) | SCN9AMAPK10CA12CA1CA2 | |
| SCHEMBL11020313 | 0.83 | CA2 (0.54) | ALDH1A1SCN9AHPGDMAPK10CA12 | |
| SCHEMBL11021552 | 0.83 | L3MBTL1 (0.47) | ALDH1A1MAPTUSP2POLBPDE4A | |
| SCHEMBL11018857 | 0.82 | MAPT (0.44) | ALDH1A1MAPTPOLBLMNASCN9A | |
| SCHEMBL11021236 | 0.81 | KDM4E (0.42) | ALDH1A1MAPTPKMUSP2POLB | |
| SCHEMBL11018077 | 0.80 | CYP2C9 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |