Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 6/20 | 0.38 |
| ▸ | ACACA | Q13085 | 6/20 | 0.38 |
| ▸ | PGR | P06401 | 4/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | MST1R | Q04912 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2677397 | 0.82 | ACACB (0.41) | ACACBACACAPGRRECQL | |
| SCHEMBL8555344 | 0.80 | CACNB4 (0.38) | PGRMAPK1TP53MAPTGAA | |
| SCHEMBL11027190 | 0.80 | ALDH1A1 (0.39) | MAPTKDM4EALDH1A1GAA | |
| SCHEMBL1550368 | 0.78 | PGR (0.42) | ACACBACACAPGRTDP2MAPT | |
| SCHEMBL6211150 | 0.76 | PGR (0.52) | PGRTDP2 | |
| SCHEMBL2759720 | 0.76 | ACACB (0.42) | ACACBACACAPGRTDP2 | |
| SCHEMBL5231465 | 0.76 | SLC9A1 (0.41) | RECQLTP53MAPTGAATSHR | |
| SCHEMBL812654 | 0.75 | PGR (0.50) | PGRTDP2 | |
| SCHEMBL27698252 | 0.74 | PGR (0.39) | ACACBACACAPGRTDP2 | |
| SCHEMBL11030508 | 0.73 | DDB1 (0.44) | GSK3BMAPK1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106905215-B | Process for preparing 1-H-pyrrolidine-2, 4-dione derivatives | 拜耳知识产权有限责任公司 | 2021-10-01 | — | — | CN | disclosed |
| EP-3372580-B1 | METHOD FOR THE PREPARATION OF 1-H-PYRROLIDIN-2,4-DIONE-DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2020-07-22 | — | — | EP | disclosed |
| EP-3372580-A1 | METHOD FOR THE PREPARATION OF 1-H-PYRROLIDIN-2,4-DIONE-DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2018-09-12 | — | — | EP | disclosed |
| EP-2668158-B1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | BAYER IP GMBH (DE) | 2018-06-27 | — | — | EP | disclosed |
| US-9272997-B2 | Process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20140371468-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2014-12-18 | — | — | US | disclosed |
| US-8859782-B2 | Process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2014-10-14 | — | — | US | disclosed |
| EP-2668158-A1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | Bayer Intellectual Property GmbH (DE) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101047-A1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2012-08-02 | — | — | WO | disclosed |
| US-20120190865-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | BAYER CROPSCIENCE AG (DE) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190865-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | DHPS, HPD, DOHH | ACACB 4094/4885ACACA 4346/4885PGR 3190/4885 |
| US-20140371468-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | DHPS, HPD, DOHH | ACACB 4094/4885ACACA 4346/4885PGR 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.