Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11890184 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9ANPC1CYP3A4 | |
| SCHEMBL15711568 | 0.80 | ESR1 (0.45) | ALDH1A1CYP3A4MAPTMEN1LMNA | |
| SCHEMBL13470060 | 0.78 | TTR (0.57) | ALDH1A1CYP3A4HPGDALOX15HSD17B10 | |
| SCHEMBL8482187 | 0.77 | MAPT (0.49) | ALDH1A1RAB9ANPC1CYP3A4MAPT | |
| SCHEMBL8482189 | 0.77 | MAPT (0.49) | ALDH1A1RAB9ANPC1CYP3A4MAPT | |
| SCHEMBL34468091 | 0.76 | KDM4E (0.72) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL3565699 | 0.76 | KDM4E (0.72) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL3565700 | 0.76 | KDM4E (0.72) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL22147339 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KDM4ERAB9ANPC1CYP3A4 | |
| SCHEMBL1832142 | 0.74 | MAPT (0.44) | ALDH1A1KDM4ECYP3A4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385934-B1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | COUNCIL SCIENT IND RES (IN) | 2016-05-18 | — | — | EP | disclosed |
| US-9302967-B2 | Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-04-05 | — | — | US | disclosed |
| US-9290473-B2 | Inhibitors of phosphatidylinositol-3-kinase (PI3) and inducers of nitric oxide (NO) | COUCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-03-22 | — | — | US | disclosed |
| US-20140135393-A1 | SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-05-15 | — | — | US | disclosed |
| WO-2012140574-A1 | SUBSTITUTED CATECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-10-18 | — | — | WO | disclosed |
| US-20120190738-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135393-A1 | SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA | IL5, IL4, IL33 | ALDH1A1 1102/4885KDM4E 1050/4885RAB9A 4451/4885 |
| US-20120190738-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | NOS2, NOS3, NOS1 | ALDH1A1 2529/4885KDM4E 2859/4885RAB9A 3270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.