Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3291029 | 0.78 | HTR6 (0.62) | HTR6KDM4EALDH1A1GAAPKM | |
| SCHEMBL8852806 | 0.77 | HTR6 (0.56) | HTR6KDM4EALDH1A1GAAPKM | |
| SCHEMBL11029613 | 0.76 | PKM (0.47) | HTR6KDM4EALDH1A1GAAPKM | |
| SCHEMBL9751876 | 0.74 | HTR6 (0.45) | HTR6KDM4EGAANPSR1LMNA | |
| SCHEMBL11035149 | 0.73 | HTR6 (0.51) | HTR6KDM4EALDH1A1GAAPKM | |
| SCHEMBL6733413 | 0.73 | HTR6 (0.51) | HTR6KDM4EALDH1A1GAAPKM | |
| SCHEMBL26294642 | 0.71 | HTR6 (0.53) | HTR6KDM4EALDH1A1GAAPKM | |
| SCHEMBL15444 | 0.71 | HTR6 (0.74) | HTR6KDM4EALDH1A1GAAPKM | |
| SCHEMBL6040902 | 0.69 | MMP2 (0.53) | HTR6KDM4EGAANPSR1LMNA | |
| (Phenylsulfonyl)Benzene SCHEMBL2381369 | 0.69 | HTR6 (0.74) | HTR6KDM4EALDH1A1GAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0165422-A1 | Substituted bis-(4-aminophenyl)-sulphones, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |