SCHEMBL1103795

SCHEMBL1103795

O=C(O)c1cc(N2C(=O)C=CC2=O)ccc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12

nearest known ligand 0.69

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 3/20 0.69
▸ L3MBTL1 Q9Y468 1/20 0.69
▸ MEN1 O00255 2/20 0.58
▸ POLB P06746 2/20 0.58
▸ KMT2A Q03164 2/20 0.58
▸ ALPL P05186 1/20 0.58
▸ ALPI P09923 1/20 0.58
▸ ALPG P10696 1/20 0.58
▸ ATM Q13315 1/20 0.56
▸ PLEC Q15149 1/20 0.56
▸ CA9 Q16790 15/20 0.54
▸ CA1 P00915 13/20 0.54
▸ CA2 P00918 13/20 0.54
▸ DNASE1L3 Q13609 1/20 0.52
▸ PRMT1 Q99873 1/20 0.52
▸ CA12 O43570 5/20 0.52
▸ CA14 Q9ULX7 3/20 0.49
▸ CA7 P43166 2/20 0.48
▸ ESR1 P03372 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22651493 0.89 USP2 (0.68) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL16283416 0.88 USP2 (0.67) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL18897669 0.85 USP2 (0.62) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL12134945 0.83 USP2 (0.60) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL1437042 0.83 USP2 (0.78) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL20254033 0.82 USP2 (0.77) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL12657220 0.82 CA9 (0.58) USP2L3MBTL1CA9CA1CA2
SCHEMBL10098714 0.82 USP2 (0.76) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL30023431 0.82 USP2 (1.00) USP2L3MBTL1MEN1POLBKMT2A
SCHEMBL3481432 0.82 USP2 (1.00) USP2L3MBTL1MEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2793947-B1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2021-02-03 — — EP disclosed
US-10675359-B2 Enzymatic conjugation of antibodies INNATE PHARMA (FR) 2020-06-09 — — US disclosed
EP-3564259-A2 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION Innate Pharma (FR) 2019-11-06 — — EP disclosed
US-10434180-B2 Enzymatic conjugation of polypeptides INNATE PHARMA (FR) 2019-10-08 — — US disclosed
US-20190169601-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION INNATE PHARMA (FR) 2019-06-06 — — US disclosed
EP-2872894-B1 SCREENING OF CONJUGATED ANTIBODIES INNATE PHARMA (FR) 2019-04-17 — — EP disclosed
EP-3240573-B1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2019-03-20 — — EP disclosed
US-10132799-B2 Screening of conjugated antibodies INNATE PHARMA (FR) 2018-11-20 — — US disclosed
EP-2793949-B1 ENZYMATIC CONJUGATION OF ANTIBODIES INNATE PHARMA (FR) 2018-08-22 — — EP disclosed
US-10036010-B2 Recognition tags for TGase-mediated conjugation INNATE PHARMA (FR) 2018-07-31 — — US disclosed
US-20090118471-A1 NOVEL COUMARIN DERIVATIVES THE UNIVERSITY OF TOKYO (JP) 2009-05-07 — — US disclosed
US-7482473-B2 Coumarin derivative THE UNIVERSITY OF TOKYO (JP) 2009-01-27 — — US disclosed
US-7482473-B2 Coumarin derivative THE UNIVERSITY OF TOKYO (JP) 2009-01-27 — — US disclosed
US-7465814-B2 Sulfonate compound and fluorescent probe using the same OSAKA INDUSTRIAL PROMOTION ORGANIZATION (JP) 2008-12-16 — — US disclosed
US-7465814-B2 Sulfonate compound and fluorescent probe using the same OSAKA INDUSTRIAL PROMOTION ORGANIZATION (JP) 2008-12-16 — — US disclosed
US-7387771-B1 dissolving in carrier liquid; drug linked to a protein-binding molecule via a spacer which is cleaved hydrolytically or enzymatically in the body of a subject in a pH-dependent manner; tissue targeted delivery; Doxorubicin-phenylacetylhydrazone spacer-maleimide KTB TUMORFORSCHUNGS GMBH (DE) 2008-06-17 — — US disclosed
US-7387771-B1 dissolving in carrier liquid; drug linked to a protein-binding molecule via a spacer which is cleaved hydrolytically or enzymatically in the body of a subject in a pH-dependent manner; tissue targeted delivery; Doxorubicin-phenylacetylhydrazone spacer-maleimide KTB TUMORFORSCHUNGS GMBH (DE) 2008-06-17 — — US disclosed
US-7273920-B2 Controlling protein levels in eucaryotic organisms WELLSTAT BIOCATALYSIS, LLC (US) 2007-09-25 — — US disclosed
US-20070197778-A1 NOVEL COUMARIN DERIVATIVE THE UNIVERSITY OF TOKYO (JP) 2007-08-23 — — US disclosed
US-20070197778-A1 NOVEL COUMARIN DERIVATIVE THE UNIVERSITY OF TOKYO (JP) 2007-08-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10675359-B2 Enzymatic conjugation of antibodies DNPEP, MPO, FCGR3B USP2 862/4885L3MBTL1 4099/4885MEN1 4673/4885
US-10434180-B2 Enzymatic conjugation of polypeptides DNPEP, ENPEP, PEPD USP2 841/4885L3MBTL1 3802/4885MEN1 4381/4885
US-10132799-B2 Screening of conjugated antibodies FCGR2A, TGM2, TGM6 USP2 1063/4885L3MBTL1 1313/4885MEN1 4063/4885
US-10036010-B2 Recognition tags for TGase-mediated conjugation TGM2, TGM3, TGM6 USP2 1141/4885L3MBTL1 1846/4885MEN1 3810/4885
US-20090118471-A1 NOVEL COUMARIN DERIVATIVES CBR3, MRPS23, MRPS22 USP2 4295/4885L3MBTL1 1586/4885MEN1 451/4885
US-20190169601-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION TGM2, TGM3, TGM6 USP2 1141/4885L3MBTL1 1846/4885MEN1 3810/4885
US-20070197778-A1 NOVEL COUMARIN DERIVATIVE CBR3, MRPS22, MRPS23 USP2 4282/4885L3MBTL1 1562/4885MEN1 429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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