Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRK6 | P43250 | 2/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056304 | 0.88 | PKM (0.41) | PKMMAPTMEN1KMT2AKDM4E | |
| SCHEMBL11057681 | 0.87 | APLNR (0.39) | MAPTMEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL11051199 | 0.85 | ELANE (0.39) | PKMMAPTMEN1KMT2AKDM4E | |
| SCHEMBL11052581 | 0.85 | HCAR1 (0.48) | MEN1KMT2APOLBGAAHCAR1 | |
| SCHEMBL11056242 | 0.84 | HCAR1 (0.40) | MEN1KMT2AHCAR1TP53DHFR | |
| SCHEMBL11059402 | 0.82 | KMT2A (0.39) | PKMMAPTMEN1KMT2AKDM4E | |
| SCHEMBL11050203 | 0.81 | HCAR1 (0.37) | MAPTKDM4EL3MBTL1POLBRECQL | |
| SCHEMBL11057576 | 0.79 | ALDH1A1 (0.39) | HCAR1ALDH1A1DHFR | |
| SCHEMBL11054450 | 0.79 | HCAR1 (0.40) | KDM4EHCAR1 | |
| SCHEMBL11054591 | 0.79 | CHRNA7 (0.46) | KMT2AHCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |