Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11076201 | 0.72 | — | — | |
| SCHEMBL24603725 | 0.71 | GABRA1 (0.38) | CYP1A2CYP3A4 | |
| SCHEMBL15577016 | 0.71 | CES2 (0.32) | — | |
| SCHEMBL10391947 | 0.67 | SCN4A (0.42) | CYP1A2CYP3A4CYP2D6NFKB1PNMT | |
| SCHEMBL11079245 | 0.67 | ADRB2 (0.32) | NFKB1DPP4 | |
| SCHEMBL10192286 | 0.66 | — | — | |
| SCHEMBL11078611 | 0.66 | ALDH1A1 (0.35) | CYP1A2CYP2D6 | |
| SCHEMBL11078548 | 0.66 | PNMT (0.54) | CYP1A2CYP3A4CYP2D6NFKB1PNMT | |
| SCHEMBL11074818 | 0.66 | MAOA (0.38) | CYP1A2CYP3A4CYP2D6NFKB1PNMT | |
| SCHEMBL11096020 | 0.66 | LMNA (0.46) | CYP1A2CYP3A4CYP2D6NFKB1PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |