SCHEMBL11083785

SCHEMBL11083785

O=S1(=O)CCC(=S)Nc2ccc(Cl)cc2C1c1ccccc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 8/20 0.41
MAPT P10636 3/20 0.37
TP53 P04637 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
ALOX15 P16050 1/20 0.37
TSHR P16473 1/20 0.37
CASP1 P29466 1/20 0.37
CYP2C19 P33261 1/20 0.37
RECQL P46063 1/20 0.37
SLC8B1 Q6J4K2 1/20 0.37
CACNB4 O00305 1/20 0.35
CACNA1A O00555 1/20 0.35
CACNA1G O43497 1/20 0.35
CACNG3 O60359 1/20 0.35
CACNA1F O60840 1/20 0.35
CACNA1H O95180 1/20 0.35
CACNB3 P54284 1/20 0.35
CACNA2D1 P54289 1/20 0.35
CACNG7 P62955 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11090465 0.87 MAPT (0.45) MAPTTP53CYP1A2CYP2C9ALOX15
SCHEMBL10925308 0.77 CHRM1 (0.45) CHRM1MAPTTP53CYP1A2CYP2C9
SCHEMBL11085842 0.75 MAPT (0.55) MAPTTP53CYP1A2CYP2C9ALOX15
SCHEMBL11085833 0.70 NOS3 (0.32) CYP1A2CYP2C19HTR2AHTR2CMEN1
SCHEMBL5696272 0.70 CHRM1 (0.42) CHRM1MAPTTP53CYP1A2CYP2C9
SCHEMBL10930085 0.68 LMNA (0.51) MAPTTP53CYP1A2CYP2C9ALOX15
SCHEMBL4590461 0.67 CACNB4 (0.47) MAPTTP53CYP1A2CYP2C9ALOX15
SCHEMBL10926019 0.65 MAPT (0.60) MAPTTP53CYP1A2CYP2C9ALOX15
SCHEMBL23721282 0.64 LMNA (0.42) MAPTTP53CYP1A2CYP2C9ALOX15
SCHEMBL11079648 0.62 ALDH1A1 (0.50) MAPTTP53CYP1A2CYP2C9ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4464300-A PSYCHOTROPIC, ANXIOLYTIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1984-08-07 US disclosed