Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11090305 | 0.81 | ALDH1A1 (0.48) | EGFRHTTKDM4ENPC1RAB9A | |
| SCHEMBL16829428 | 0.78 | SIGMAR1 (0.45) | HRH3PARP1KDM4EL3MBTL1 | |
| SCHEMBL18614962 | 0.77 | PARP10 (0.52) | KDM4ELTA4HPARP10MAOBSIRT2 | |
| SCHEMBL11091056 | 0.76 | MAOB (0.46) | EGFRHRH3PARP1PARP10MAOB | |
| SCHEMBL9386875 | 0.76 | KDM4E (0.45) | HRH3PARP1KDM4EALDH1A1 | |
| SCHEMBL1873419 | 0.73 | HTR1A (0.58) | HRH3LTA4H | |
| SCHEMBL22151427 | 0.72 | LTA4H (0.79) | EGFRHRH3HTTKDM4ENPC1 | |
| SCHEMBL7907691 | 0.72 | MAOB (0.73) | NPC1RAB9ASMN1; SMN2PARP10MAOB | |
| SCHEMBL3454792 | 0.72 | PARP15 (0.62) | PARP1PARP10MAOBSIRT2 | |
| SCHEMBL162815 | 0.71 | PARP10 (0.60) | NPC1RAB9ASMN1; SMN2PARP10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443603-A | PROTEOLYTIC ENZYME INHIBITORS | KOWA COMPANY LIMITED (JP) | 1984-04-17 | — | — | US | disclosed |
| EP-0067561-A2 | Piperazine derivatives and processes for producing them | KOWA COMPANY, LTD. (JP) | 1982-12-22 | — | — | EP | disclosed |