Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL2691671 | 0.80 | RIPK1 (0.59) | RIPK1MAPK1PTGS2 | |
| SCHEMBL10812826 | 0.77 | RIPK1 (0.59) | RIPK1MAPK1PTGS2 | |
| SCHEMBL10756366 | 0.76 | RIPK1 (0.61) | RIPK1MAPK1PTGS2KMT2APOLB | |
| SCHEMBL122207 | 0.74 | MAPK1 (0.76) | RIPK1MAPK1POLB | |
| SCHEMBL10761439 | 0.73 | RIPK1 (0.60) | RIPK1MAPK1PTGS2 | |
| SCHEMBL10812821 | 0.73 | MAPK1 (0.74) | RIPK1MAPK1POLB | |
| SCHEMBL11344136 | 0.72 | KMT2A (0.56) | RIPK1MAPK1HPGDKMT2AMAPT | |
| SCHEMBL10759167 | 0.72 | MAPK1 (0.59) | RIPK1MAPK1KMT2A | |
| SCHEMBL11353800 | 0.71 | RIPK1 (0.64) | RIPK1MAPK1 | |
| SCHEMBL11399512 | 0.71 | ALDH1A1 (0.56) | RIPK1MAPK1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127313-A1 | The production of haploid seed, of doubled haploids and of homozygous plant lines therefrom | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1984-12-05 | — | — | EP | disclosed |