Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29797969 | 0.80 | GPR3 (0.46) | HTR7HTR2BPOLBMEN1KMT2A | |
| SCHEMBL4359049 | 0.80 | GPR3 (0.46) | HTR7HTR2BPOLBMEN1KMT2A | |
| SCHEMBL226371 | 0.78 | HTR7 (0.49) | HTR7HTR2BALDH1A1NPC1RAB9A | |
| SCHEMBL7137182 | 0.78 | HTR7 (0.49) | HTR7HTR2BALDH1A1NPC1RAB9A | |
| SCHEMBL1075715 | 0.76 | HTR2B (0.51) | HTR7HTR2BALDH1A1NPC1RAB9A | |
| SCHEMBL29601950 | 0.74 | CDK5 (0.54) | HTR2BALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1934646 | 0.74 | BCHE (0.46) | HTR7HTR2BALDH1A1NPC1RAB9A | |
| SCHEMBL12402581 | 0.72 | HTR2A (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL8518637 | 0.72 | ALDH1A1 (0.44) | HTR7HTR2BALDH1A1NPC1RAB9A | |
| SCHEMBL1230997 | 0.72 | HTR2A (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0092385-A2 | Hydantoin derivatives for use in inhibiting aldose reductase activity, compositions therefor and process for preparing spiro-fluoren compounds | ALCON LABORATORIES, INC. (US) | 1983-10-26 | — | — | EP | disclosed |