Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 9/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270284 | 0.83 | ALDH1A1 (0.43) | TP53LMNAALDH1A1TSHR | |
| SCHEMBL11269178 | 0.81 | DRD2 (0.38) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL11268503 | 0.74 | DRD2 (0.39) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL11261043 | 0.73 | HDAC1 (0.39) | TP53LMNAMAPTALDH1A1 | |
| SCHEMBL4039571 | 0.71 | KMT2A (0.64) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL11252945 | 0.69 | DRD2 (0.48) | NPC1RAB9ATP53ALDH1A1TSHR | |
| SCHEMBL11251039 | 0.67 | CLK1 (0.57) | POLBMAPTMEN1KMT2AKDM4E | |
| SCHEMBL11267504 | 0.66 | DRD2 (0.41) | NPC1RAB9ALMNAPOLBMAPT | |
| SCHEMBL4558670 | 0.66 | ALDH1A1 (0.50) | POLBMAPTMEN1KMT2AKDM4E | |
| SCHEMBL11251027 | 0.66 | HTR2C (0.39) | NPC1RAB9ATP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344946-A | ANTIARTHRITICS, ANTIRHEUMATICS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-17 | — | — | US | disclosed |