Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 10/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | RORA | P35398 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270933 | 0.87 | MLYCD (0.39) | MLYCDSMN1; SMN2NR1H3NR1H2 | |
| SCHEMBL11264346 | 0.86 | TACR1 (0.32) | — | |
| SCHEMBL11261894 | 0.82 | PGR (0.38) | MLYCDSMN1; SMN2NR1H3MAPK1LMNA | |
| SCHEMBL11261306 | 0.82 | POLB (0.45) | MLYCDSMN1; SMN2NR1H3LMNANR1H2 | |
| SCHEMBL11262896 | 0.78 | RORC (0.36) | SMN1; SMN2NR1H3GAAMAPK1LMNA | |
| SCHEMBL11625441 | 0.75 | MLYCD (0.37) | MLYCDSMN1; SMN2 | |
| SCHEMBL11270936 | 0.74 | RXRA (0.33) | MLYCDLMNANPSR1 | |
| SCHEMBL11410783 | 0.72 | L3MBTL1 (0.38) | MLYCDSMN1; SMN2NR1H3MAPK1NR1H2 | |
| SCHEMBL11346211 | 0.70 | CA1 (0.50) | NR1H3GAALMNANR1H2 | |
| SCHEMBL11261308 | 0.69 | L3MBTL1 (0.41) | MLYCDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322434-A | N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4267193-A | N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1981-05-12 | — | — | US | disclosed |