SCHEMBL1127204

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1126650	0.89	THRB (0.41)	THRBSMN1; SMN2GABRA1GABRG2GABRB3
	SCHEMBL15161896	0.83	CNR1 (0.38)	THRBGRIA2GRIA4GABRA1GABRG2
	SCHEMBL15162319	0.81	THRB (0.36)	THRBSMN1; SMN2GRIA2GRIA4GABRA1
	SCHEMBL1126731	0.80	MMP1 (0.41)	THRBSMN1; SMN2GRIA2GRIA4GABRA1
	SCHEMBL1991484	0.79	THRB (0.40)	THRBSMN1; SMN2GRIA2GRIA4GABRA1
	SCHEMBL15162096	0.78	THRB (0.39)	THRBSMN1; SMN2GABRA1GABRG2GABRB3
	SCHEMBL23488097	0.75	THRB (0.40)	THRBSMN1; SMN2L3MBTL1KDM4EALDH1A1
	SCHEMBL1993379	0.72	GABRA1 (0.40)	THRBSMN1; SMN2GABRA1GABRG2GABRB3
	SCHEMBL1127116	0.72	LMNA (0.42)	THRBSMN1; SMN2L3MBTL1GABRA2GABRB2
	SCHEMBL1126938	0.72	KDM4E (0.43)	THRBSMN1; SMN2GABRA2GABRB2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.