Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL8587575 | 0.97 | LMNA (0.59) | LMNAMEN1KMT2ACASP1CYP1A2 | |
| SCHEMBL10800782 | 0.82 | CASP1 (0.47) | LMNACASP1CYP1A2 | |
| SCHEMBL3622950 | 0.77 | CASP1 (0.39) | LMNAMEN1KMT2ACASP1CYP1A2 | |
| Tromethamine SCHEMBL11881550 | 0.75 | MEN1 (0.83) | LMNAMEN1KMT2A | |
| Tromethamine SCHEMBL975 | 0.74 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.74 | — | — | |
| Tromethamine SCHEMBL17484 | 0.74 | MEN1 (1.00) | LMNAMEN1KMT2A | |
| Tromethamine SCHEMBL16418078 | 0.74 | MEN1 (0.59) | LMNAMEN1KMT2A | |
| SCHEMBL7190354 | 0.72 | NUDT1 (0.47) | LMNACASP1CYP1A2NUDT1 | |
| Tromethamine SCHEMBL28513840 | 0.72 | MEN1 (0.77) | LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034668-A2 | Adhesion of textile cords to rubber using a butadiene-styrene-vinylpyridine rubber latex and an aminoplast resin | AMERICAN CYANAMID COMPANY (US) | 1981-09-02 | — | — | EP | disclosed |
| US-4263190-A | DIPPING FIBERS, IMBEDDING IN RUBBER | AMERICAN CYANAMID COMPANY (US) | 1981-04-21 | — | — | US | disclosed |