Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11408555 | 0.87 | RAPGEF4 (0.39) | TDP1ALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL21779630 | 0.79 | TDP1 (0.39) | TDP1ALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL8359921 | 0.79 | TDP1 (0.50) | TDP1ALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL17828144 | 0.77 | GPR55 (0.38) | TDP1ALDH1A1ELANE | |
| SCHEMBL7767529 | 0.76 | TDP1 (0.52) | TDP1ALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL10024341 | 0.76 | TDP1 (0.55) | TDP1ALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL11444008 | 0.74 | TDP1 (0.35) | TDP1ALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL3190908 | 0.74 | RAPGEF4 (0.39) | ALDH1A1ALOX15HSD17B10L3MBTL1ALOX12 | |
| SCHEMBL11409853 | 0.73 | TDP1 (0.38) | TDP1ALDH1A1ALOX15HSD17B10L3MBTL1 | |
| SCHEMBL28806252 | 0.72 | PTGS2 (0.48) | TDP1ALDH1A1ALOX15HSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3245213-B1 | BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING | BRISTOL MYERS SQUIBB CO (US) | 2020-03-04 | — | — | EP | disclosed |
| US-9527871-B2 | Benzodiazepine dimers, conjugates thereof, and methods of making and using | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160200742-A1 | BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING | BRISTOL-MYERS SQUIBB COMPANY | 2016-07-14 | — | — | US | disclosed |
| US-4196142-A | 2-Chloro-n-isopropyl-3,5-disubstituted or 3,4,5-trisubstitutes lower alkyl acetanilides as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1980-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200742-A1 | BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING | GABRA1, GABRA3, GABRA2 | TDP1 2786/4885ALDH1A1 164/4885ALOX15 3715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.