Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456856 | 0.89 | DRD2 (0.46) | DRD2OPRL1SIGMAR1POLBMEN1 | |
| SCHEMBL11454487 | 0.88 | MEN1 (0.48) | DRD2OPRL1MEN1KMT2AOPRM1 | |
| SCHEMBL11446528 | 0.88 | DRD2 (0.50) | DRD2OPRL1SIGMAR1POLBMEN1 | |
| SCHEMBL11455002 | 0.83 | OPRM1 (0.42) | OPRL1OPRM1 | |
| SCHEMBL11457535 | 0.81 | HTR7 (0.59) | DRD2KMT2A | |
| SCHEMBL11454403 | 0.80 | CARM1 (0.49) | DRD2SIGMAR1 | |
| SCHEMBL11447323 | 0.77 | ALDH1A1 (0.41) | POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL11446043 | 0.76 | HTR7 (0.62) | DRD2 | |
| SCHEMBL11465441 | 0.74 | ADRA1A (0.42) | DRD2OPRM1ALDH1A1 | |
| SCHEMBL6797005 | 0.74 | DRD2 (0.59) | DRD2SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4207324-A | DIURETICS, HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-06-10 | — | — | US | disclosed |
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |