Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11465462 | 1.00 | OPRM1 (0.45) | OPRM1MLYCDKDM2BSIGMAR1KDM4E | |
| SCHEMBL11447020 | 0.84 | OPRD1 (0.42) | OPRM1SIGMAR1KDM4EALDH1A1OPRD1 | |
| SCHEMBL11456891 | 0.83 | MEN1 (0.42) | OPRM1SIGMAR1CHRM3OPRD1OPRK1 | |
| SCHEMBL11447557 | 0.82 | OPRM1 (0.50) | OPRM1SIGMAR1KDM4EALDH1A1SLC22A1 | |
| SCHEMBL11347007 | 0.80 | SIGMAR1 (0.43) | OPRM1SIGMAR1KDM4EALDH1A1POLB | |
| SCHEMBL11334220 | 0.79 | MEN1 (0.44) | OPRM1SIGMAR1POLBCHRM3OPRD1 | |
| SCHEMBL11341610 | 0.79 | KDM4E (0.50) | OPRM1SIGMAR1KDM4EALDH1A1OPRD1 | |
| Eclanamine SCHEMBL29388487 | 0.77 | OPRK1 (0.41) | OPRM1SIGMAR1ALDH1A1OPRD1OPRK1 | |
| Eclanamine SCHEMBL2109152 | 0.77 | OPRK1 (0.41) | OPRM1SIGMAR1ALDH1A1OPRD1OPRK1 | |
| Eclanamine SCHEMBL11446626 | 0.77 | OPRK1 (0.41) | OPRM1SIGMAR1ALDH1A1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4204003-A | N-(2-Aminocyclopentyl)-N-alkanoylanilides as CNS anti-depressants | THE UPJOHN COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4159340-A | N-(2-Aminocyclopentyl)-N-acylanilides as CNS anti-depressants | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4156015-A | N-(2-Aminocyclopentyl)acylanilides and treating depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |
| US-4148913-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-04-10 | — | — | US | disclosed |