Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PTGES | O14684 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243005 | 0.77 | NPSR1 (0.58) | TP53LMNAPTGESMAPTNPSR1 | |
| SCHEMBL11470519 | 0.74 | LMNA (0.41) | TP53LMNAPTGESMAPTNPSR1 | |
| SCHEMBL11467226 | 0.73 | NPSR1 (0.47) | LMNAPTGESMAPTNPSR1ALDH1A1 | |
| SCHEMBL11478727 | 0.72 | LMNA (0.48) | TP53LMNAPTGESMAPTNPSR1 | |
| SCHEMBL11479740 | 0.71 | PTGES (0.73) | TP53LMNAPTGESMAPTPTGS2 | |
| SCHEMBL11483110 | 0.69 | TP53 (0.47) | TP53LMNAPTGESMAPTNPSR1 | |
| SCHEMBL11468991 | 0.69 | WDR5 (0.37) | TP53LMNAMAPTNPSR1ALDH1A1 | |
| SCHEMBL11477775 | 0.68 | WDR5 (0.36) | TP53LMNAMAPTNPSR1ALDH1A1 | |
| SCHEMBL11712304 | 0.67 | PTGES (0.43) | TP53LMNAPTGESMAPTALDH1A1 | |
| SCHEMBL11467215 | 0.67 | SCN9A (0.40) | TP53LMNAPTGESMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |