Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.52 |
| ▸ | CA2 | P00918 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium SCHEMBL11516876 | 0.83 | CA1 (0.54) | CA1CA2MEN1KMT2APOLB | |
| SCHEMBL11516870 | 0.83 | CA1 (0.54) | CA1CA2MEN1KMT2APOLB | |
| Potassium Ion SCHEMBL11518545 | 0.82 | CA1 (0.53) | CA1CA2MEN1KMT2APOLB | |
| Potassium Ion SCHEMBL9864416 | 0.81 | CA1 (0.57) | CA1CA2MEN1KMT2AMAPT | |
| SCHEMBL29466714 | 0.81 | CA1 (0.55) | CA1CA2MEN1KMT2APOLB | |
| SCHEMBL7933997 | 0.79 | CA1 (0.50) | CA1CA2MEN1KMT2APOLB | |
| Potassium Ion SCHEMBL11522100 | 0.79 | ALDH1A1 (0.49) | CA1CA2MEN1KMT2AMAPT | |
| SCHEMBL3022742 | 0.76 | PKM (0.56) | POLBPKMALDH1A1 | |
| SCHEMBL7932539 | 0.74 | ALDH1A1 (0.58) | MEN1KMT2APOLBMAPTL3MBTL1 | |
| SCHEMBL14202768 | 0.74 | ALDH1A1 (0.59) | MEN1KMT2APOLBMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4178301-A | 4-(2-(ACETYLTHIO)ACETAMIDO)BENZOIC ACID AS MUCOLYTIC AGENT | MEAD JOHNSON & COMPANY (US) | 1979-12-11 | — | — | US | disclosed |
| US-4132802-A | LIQUEFACTION OF MUCUS | MEAD JOHNSON & COMPANY (US) | 1979-01-02 | — | — | US | disclosed |
| US-4096277-A | Mucolytic mercaptoacylamidobenzamides and process of using same | MEAD JOHNSON & COMPANY (US) | 1978-06-20 | — | — | US | disclosed |
| US-4005222-A | Mucolytic mercaptoacylamidobenzoic and benzenesulfonic acid compounds and process | MEAD JOHNSON & COMPANY (US) | 1977-01-25 | — | — | US | disclosed |