Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium SCHEMBL11522106 | 0.85 | CASR (0.51) | ALDH1A1MAPTKMT2ACA1CA2 | |
| SCHEMBL11522095 | 0.85 | CASR (0.51) | ALDH1A1MAPTKMT2ACA1CA2 | |
| Potassium Ion SCHEMBL11519125 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTKMT2ACA1CA2 | |
| SCHEMBL29466714 | 0.81 | CA1 (0.55) | ALDH1A1MAPTKMT2ACA1CA2 | |
| Potassium Ion SCHEMBL11516871 | 0.79 | CA1 (0.52) | ALDH1A1MAPTKMT2ACA1CA2 | |
| SCHEMBL3022742 | 0.77 | PKM (0.56) | ALDH1A1SMN1; SMN2HSD17B10 | |
| Potassium Ion SCHEMBL9864416 | 0.76 | CA1 (0.57) | MAPTKMT2ACA1CA2MEN1 | |
| SCHEMBL11519255 | 0.75 | ALDH1A1 (0.50) | ALDH1A1CA1CA2L3MBTL1HDAC3 | |
| SCHEMBL11519123 | 0.73 | ALDH1A1 (0.49) | ALDH1A1CA1CA2L3MBTL1HDAC3 | |
| SCHEMBL11521462 | 0.73 | RAB9A (0.65) | ALDH1A1MAPTKMT2ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4178301-A | 4-(2-(ACETYLTHIO)ACETAMIDO)BENZOIC ACID AS MUCOLYTIC AGENT | MEAD JOHNSON & COMPANY (US) | 1979-12-11 | — | — | US | disclosed |
| US-4132802-A | LIQUEFACTION OF MUCUS | MEAD JOHNSON & COMPANY (US) | 1979-01-02 | — | — | US | disclosed |
| US-4096277-A | Mucolytic mercaptoacylamidobenzamides and process of using same | MEAD JOHNSON & COMPANY (US) | 1978-06-20 | — | — | US | disclosed |
| US-4005222-A | Mucolytic mercaptoacylamidobenzoic and benzenesulfonic acid compounds and process | MEAD JOHNSON & COMPANY (US) | 1977-01-25 | — | — | US | disclosed |