Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 3/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11607595 | 0.87 | PTGER1 (0.46) | RHEBMRGPRX4NR4A2KMT2AKDM4E | |
| SCHEMBL11532625 | 0.87 | SRD5A2 (0.55) | NR4A2KMT2AKDM4EMAPTTDP1 | |
| SCHEMBL11538794 | 0.86 | RXRA (0.49) | RHEBMRGPRX4KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL11531739 | 0.86 | KDM4E (0.45) | RHEBMRGPRX4KDM4EMAPTHPGD | |
| SCHEMBL18989127 | 0.78 | LMNA (0.47) | KMT2AMAPTTDP1HPGDSMN1; SMN2 | |
| SCHEMBL11605247 | 0.72 | TSHR (0.49) | KMT2AKDM4EMAPTTDP1HPGD | |
| SCHEMBL11606291 | 0.72 | XDH (0.46) | PTGER1XDHALDH1A1 | |
| SCHEMBL11607350 | 0.72 | CNR2 (0.47) | HPGDXDHALDH1A1 | |
| SCHEMBL20536128 | 0.71 | RHEB (1.00) | RHEBMRGPRX4NR4A2KMT2AKDM4E | |
| SCHEMBL11591989 | 0.71 | ALDH1A1 (0.47) | KMT2ATDP1HPGDMMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156728-A | HYPOTENSIVE | MEIJI SEIKA KAISHA, LTD. (JP) | 1979-05-29 | — | — | US | disclosed |
| US-4083850-A | HYPOTENSIVE AGENTS | MEIJI SEIKA KAISHA LTD. (JA) | 1978-04-11 | — | — | US | disclosed |