Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 9/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 6/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.39 |
| ▸ | TNKS | O95271 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.39 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.39 |
| ▸ | PARP16 | Q8N5Y8 | 2/20 | 0.39 |
| ▸ | PARP12 | Q9H0J9 | 2/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.39 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.39 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.39 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537172 | 0.76 | DCTPP1 (0.34) | DCTPP1PARP2PARP15TNKS2PARP10 | |
| SCHEMBL11534867 | 0.68 | ICMT (0.36) | DCTPP1TSHRSMN1; SMN2HPGDKDM4E | |
| SCHEMBL11533488 | 0.66 | PARP10 (0.35) | DCTPP1PARP2PARP15TNKS2PARP10 | |
| SCHEMBL11532883 | 0.62 | LMNA (0.32) | DCTPP1LMNATSHRMAPK1HTT | |
| SCHEMBL13548279 | 0.60 | HMGCR (0.48) | KDM4E | |
| SCHEMBL14405826 | 0.59 | HMGCR (0.39) | PDE3AKDM4E | |
| SCHEMBL14764825 | 0.57 | PDE10A (0.58) | SMN1; SMN2PDE2APDE4DPDE3APDE10A | |
| SCHEMBL15682035 | 0.57 | CA2 (0.47) | LMNATSHRMAPK1HTTKDM4E | |
| SCHEMBL2439171 | 0.57 | HMGCR (0.34) | PDE3AKDM4EALDH1A1 | |
| SCHEMBL18504999 | 0.56 | ALDH1A1 (0.37) | PARP2PARP15TNKS2PARP10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134914-A | 1-Acyl-4-substituted phenyl thiosemicarbazides | ELI LILLY AND COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4082762-A | 4-(2-HALOPHENYL)-1,2,4-TRIAZOLE-3-THIOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-3937713-A | Process for the preparation of s-triazolo[3,4-b]benzothiazoles | ELI LILLY AND COMPANY (US) | 1976-02-10 | — | — | US | disclosed |