SCHEMBL1153638

SCHEMBL1153638

O=C(O)CCCC(S)(S)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.48
SLC22A6 Q4U2R8 2/20 0.48
TSHR P16473 5/20 0.46
NFKB1 P19838 2/20 0.46
PMP22 Q01453 1/20 0.46
FOLH1 Q04609 1/20 0.44
CAMK2A Q9UQM7 1/20 0.42
HDAC11 Q96DB2 4/20 0.40
KMT2A Q03164 3/20 0.40
GABRR3 A8MPY1 1/20 0.40
GABRP O00591 1/20 0.40
GABRD O14764 1/20 0.40
HDAC3 O15379 1/20 0.40
GABBR2 O75899 1/20 0.40
CYP1A2 P05177 1/20 0.40
THRB P10828 1/20 0.40
GABRA1 P14867 1/20 0.40
GABRB1 P18505 1/20 0.40
GABRG2 P18507 1/20 0.40
GABRR1 P24046 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11733994 0.76 LMNA (0.43) LMNASLC22A6TSHRNFKB1PMP22
SCHEMBL3877478 0.75 LMNA (0.48) LMNASLC22A6TSHRNFKB1PMP22
SCHEMBL4555960 0.75 AKR1B1 (0.39) SLC22A6TSHRHDAC11KMT2AGPR84
SCHEMBL3361168 0.75 LMNA (0.48) LMNASLC22A6TSHRNFKB1PMP22
SCHEMBL1751918 0.75 LMNA (0.48) LMNASLC22A6TSHRNFKB1PMP22
SCHEMBL1032545 0.74 LMNA (0.53) LMNASLC22A6TSHRNFKB1PMP22
SCHEMBL5149403 0.74 LMNA (0.53) LMNASLC22A6TSHRNFKB1PMP22
SCHEMBL8202305 0.74 LMNA (0.53) LMNASLC22A6TSHRNFKB1PMP22
SCHEMBL10919501 0.73 CAMK2A (0.46) LMNASLC22A6TSHRNFKB1PMP22
SCHEMBL28456788 0.73 TSHR (0.50) LMNASLC22A6TSHRNFKB1PMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160199534-A1 DRESSING COMPOSITIONS AND METHODS NIH - DEITR 2016-07-14 US claimed
US-9211358-B2 Dressing compositions and methods RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2015-12-15 US claimed
US-20110033503-A1 DRESSING COMPOSITIONS AND METHODS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2011-02-10 US claimed
WO-2008133918-A1 DRESSING COMPOSITIONS AND METHODS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2008-11-06 WO claimed
US-6623726-B2 Wrapping hair in multilayered, deformable sheets of material having a first perforated, deformable, semi-rigid layer, and a second layer containing a thiol reducing composition, shaping, then oxidizing L'OREAL S.A. (FR) 2003-09-23 US claimed
US-20020094321-A1 Process for permanent reshaping of hair L'OREAL, S.A. (FR) 2002-07-18 US claimed
WO-2002043679-A2 PROCESS FOR PERMANENT RESHAPING OF HAIR L'OREAL S.A. (FR) 2002-06-06 WO claimed
EP-0455457-A2 Permanent wave hair composition containing transition metal oxide compounds UNILEVER PLC (GB) 1991-11-06 EP claimed
US-5061483-A TO RE-FORM RUPTURED DISULFIDE LINKAGES CHESEBROUGH-POND'S INC. (US) 1991-10-29 US claimed
EP-4729131-A2 METHODS FOR FIXING HAIR AND SKIN Olaplex, Inc. (US) 2026-04-22 EP disclosed
EP-4008306-B1 METHODS FOR FIXING HAIR AND SKIN OLAPLEX INC (US) 2026-01-28 EP disclosed
US-20250381425-A1 METHODS FOR FIXING HAIR AND SKIN OLAPLEX INC (US) 2025-12-18 US disclosed
US-20250302704-A1 METHODS FOR FIXING HAIR AND SKIN GOLDMAN SACHS BANK USA 2025-10-02 US disclosed
US-12257330-B2 Hair coloring compositions and methods of use L'OREAL (FR) 2025-03-25 US disclosed
EP-0395332-A1 Hair treatment composition UNILEVER PLC (GB) 1990-10-31 EP disclosed
US-4898726-A Initiated hair straightening composition and system JOHNSON PRODUCTS CO., INC. (US) 1990-02-06 US disclosed
US-4812307-A PERMANENT WAVES CHESEBROUGH-POND'S INC. (US) 1989-03-14 US disclosed
EP-0305128-A1 Hair treatment process UNILEVER PLC (GB) 1989-03-01 EP disclosed
EP-0299764-A2 Hair treatment product UNILEVER PLC (GB) 1989-01-18 EP disclosed
US-4297429-A COMPLEXING A SILVER HALIDE EMULSION AND AN O-MERCAPTOBENZOIC ACID DERIVATIVE; PHOTOLITHOGRAPHY MITSUBISHI PAPER MILLS, LTD. (JP) 1981-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302704-A1 METHODS FOR FIXING HAIR AND SKIN KRT18, CUTA, COL14A1 LMNA 434/4885SLC22A6 3313/4885TSHR 4583/4885
US-12257330-B2 Hair coloring compositions and methods of use SGMS1, PHOSPHO1, SGMS2 LMNA 1805/4885SLC22A6 639/4885TSHR 4268/4885
US-20020094321-A1 Process for permanent reshaping of hair GPX4, SHMT2, CUTA LMNA 1658/4885SLC22A6 2531/4885TSHR 3223/4885
US-20250381425-A1 METHODS FOR FIXING HAIR AND SKIN CUTA, SUCLG1, TST LMNA 1250/4885SLC22A6 2810/4885TSHR 3461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.