Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271333 | 0.86 | KDM4E (0.67) | L3MBTL1KDM4ECYP2D6TSHRHIF1A | |
| SCHEMBL11538263 | 0.84 | TSHR (0.68) | L3MBTL1KDM4ECYP2D6TSHRHIF1A | |
| SCHEMBL5878421 | 0.82 | L3MBTL1 (0.77) | L3MBTL1KDM4ECYP2D6TSHRHIF1A | |
| SCHEMBL24322808 | 0.82 | L3MBTL1 (0.77) | L3MBTL1KDM4ECYP2D6TSHRHIF1A | |
| SCHEMBL11543765 | 0.82 | KDM4E (0.57) | L3MBTL1KDM4ECYP2D6TSHRHIF1A | |
| Dimethylamine SCHEMBL7279750 | 0.77 | L3MBTL1 (0.69) | L3MBTL1KDM4ECYP2D6TSHRHIF1A | |
| SCHEMBL27945286 | 0.75 | LTA4H (0.54) | KDM4ESIGMAR1LTA4HKMT2AMEN1 | |
| SCHEMBL9808111 | 0.74 | LMNA (0.56) | L3MBTL1KDM4ECYP2D6ALDH1A1LMNA | |
| SCHEMBL211606 | 0.72 | LTA4H (0.77) | KDM4ESIGMAR1LTA4HKMT2AMEN1 | |
| SCHEMBL9122265 | 0.72 | LTA4H (0.77) | KDM4ESIGMAR1LTA4HKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4170653-A | Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers | Ayerst McKenna and Harrison Limited (CA) | 1979-10-09 | — | — | US | disclosed |
| US-4060613-A | ANTIDEPRESSANT | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-11-29 | — | — | US | disclosed |