Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271333 | 0.86 | KDM4E (0.67) | KDM4EL3MBTL1RAB9ATSHRCYP2D6 | |
| SCHEMBL11538263 | 0.84 | TSHR (0.68) | KDM4EL3MBTL1RAB9ATP53TSHR | |
| SCHEMBL14076209 | 0.84 | L3MBTL1 (0.64) | KDM4EGLAL3MBTL1NPC1RAB9A | |
| SCHEMBL6131254 | 0.82 | KDM4E (0.85) | KDM4EGLAL3MBTL1TSHRCYP2D6 | |
| SCHEMBL11539710 | 0.82 | L3MBTL1 (0.51) | KDM4EL3MBTL1TSHRCYP2D6HIF1A | |
| SCHEMBL11541529 | 0.78 | TSHR (0.75) | KDM4EL3MBTL1TP53TSHRCYP2D6 | |
| SCHEMBL9808111 | 0.74 | LMNA (0.56) | KDM4EL3MBTL1CYP2D6ALDH1A1LMNA | |
| SCHEMBL12406933 | 0.74 | LTA4H (0.77) | NPC1RAB9AMEN1KMT2ALTA4H | |
| SCHEMBL4579550 | 0.73 | KDM4E (1.00) | KDM4EGLAL3MBTL1TSHRCYP2D6 | |
| SCHEMBL19091219 | 0.72 | RAB9A (0.79) | KDM4ENPC1RAB9ALTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4170653-A | Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers | Ayerst McKenna and Harrison Limited (CA) | 1979-10-09 | — | — | US | disclosed |
| US-4166185-A | ANTICONVULSANTS, ANXIOLYTICS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-08-28 | — | — | US | disclosed |
| US-4147875-A | ANTIDEPRESSANTS, ANTICONBULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4146722-A | SEDATIVES, MUSCLE RELAXANTS, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4125726-A | SEDATIVES, MUSCLE RELAXANTS, ANXIOLYTICS, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1978-11-14 | — | — | US | disclosed |
| US-4060613-A | ANTIDEPRESSANT | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-11-29 | — | — | US | disclosed |