Sugi Predict

Sugi Predict / Compounds / SCHEMBL1154723

SCHEMBL1154723

SCHEMBL1154723

CC(O)c1c(F)cccc1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CES2 O00748 5/20 0.48
▸ CES1 P23141 5/20 0.48
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ ACHE P22303 1/20 0.36
▸ BCHE P06276 1/20 0.34
▸ CYP3A4 P08684 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ HPGD P15428 2/20 0.33
▸ TSHR P16473 2/20 0.33
▸ FAAH O00519 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ GABRA1 P14867 1/20 0.33
▸ GABRB1 P18505 1/20 0.33
▸ GABRG2 P18507 1/20 0.33
▸ PTGS1 P23219 1/20 0.33
▸ SLC6A2 P23975 1/20 0.33
▸ HTR2C P28335 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20238836 1.00 CES2 (0.48) CES2CES1MEN1KMT2AACHE
SCHEMBL22339022 1.00 CES2 (0.48) CES2CES1MEN1KMT2AACHE
SCHEMBL25356703 0.95 CES2 (0.45) CES2CES1MEN1KMT2AACHE
SCHEMBL17471748 0.86 CES2 (0.42) CES2CES1MEN1KMT2ACYP3A4
SCHEMBL22728357 0.86 ACHE (0.46) CES2CES1MEN1KMT2AACHE
SCHEMBL29959360 0.84 CES2 (0.41) CES2CES1CYP3A4LMNAHPGD
SCHEMBL6745071 0.84 CES2 (0.41) CES2CES1MEN1KMT2AACHE
SCHEMBL23212814 0.84 CES2 (0.41) CES2CES1CYP3A4LMNAHPGD
SCHEMBL28542075 0.84 CES2 (0.41) CES2CES1MEN1KMT2AACHE
SCHEMBL1396928 0.84 CES2 (0.41) CES2CES1CYP3A4LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12540131-B2 N-(heteroaryl) quinazolin-2-amine derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof MERCK SHARP & DOHME LLC (US) 2026-02-03 — — US claimed
CN-119306568-A Synthesis method of 2, 6-difluorostyrene 山东京博农化科技股份有限公司 2025-01-14 — — CN claimed
CN-119219464-A Synthesis method of 2, 6-difluorostyrene 山东京博农化科技股份有限公司 2024-12-31 — — CN claimed
US-20230023066-A1 N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF MERCK SHARP & DOHME CORP. (US) 2023-01-26 — — US claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 — — US claimed
EP-2736901-A1 HETEROCYCLYL PYRIMIDINE ANALOGUES AS JAK INHIBITORS Cellzome Limited (GB) 2014-06-04 — — EP claimed
WO-2013014162-A1 HETEROCYCLYL PYRIMIDINE ANALOGUES AS JAK INHIBITORS CELLZOME LIMITED (GB) 2013-01-31 — — WO claimed
US-20260000642-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS TAY THERAPEUTICS LTD (GB) 2026-01-01 — — US disclosed
US-20260001864-A1 COMPOUND CONTAINING SULFAMIDE STRUCTURE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION NANJING SHUOHUI PHARMATECHNOLOGY CO., LTD (CN) 2026-01-01 — — US disclosed
US-20250263370-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS Tay Therapeutics Limited (GB) 2025-08-21 — — US disclosed
EP-4558224-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS Tay Therapeutics Limited (GB) 2025-05-28 — — EP disclosed
CN-119306568-A Synthesis method of 2, 6-difluorostyrene 山东京博农化科技股份有限公司 2025-01-14 — — CN disclosed
CN-119306568-A Synthesis method of 2, 6-difluorostyrene 山东京博农化科技股份有限公司 2025-01-14 — — CN disclosed
EP-0248414-B1 ARALKYL IMIDAZOLE DERIVATIVES CIBA-GEIGY AG (CH) 1992-09-23 — — EP disclosed
US-4851424-A 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy CIBA-GEIGY CORPORATION (US) 1989-07-25 — — US disclosed
US-4789680-A Aralkyltriazole compounds CIBA-GEIGY CORPORATION (US) 1988-12-06 — — US disclosed
EP-0248414-A2 Aralkyl imidazole derivatives CIBA-GEIGY AG (CH) 1987-12-09 — — EP disclosed
EP-0199262-A2 Fluorinated benzyl triazole compounds CIBA-GEIGY AG (CH) 1986-10-29 — — EP disclosed
US-4438271-A HERBICIDES UNIROYAL, INC. (US) 1984-03-20 — — US disclosed
EP-0079154-A2 2-Ethylsulfonyl pyridine 1-oxide derivatives UNIROYAL, INC. (US) 1983-05-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12540131-B2 N-(heteroaryl) quinazolin-2-amine derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof LRRK2, PARK7, SNCA CES2 2482/4885CES1 2450/4885MEN1 3559/4885
US-20260001864-A1 COMPOUND CONTAINING SULFAMIDE STRUCTURE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION SLC10A2, SLC6A11, ABCB11 CES2 1473/4885CES1 202/4885MEN1 3372/4885
US-20230023066-A1 N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF LRRK2, CLK2, PARK7 CES2 3697/4885CES1 4421/4885MEN1 3746/4885
US-20260000642-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS BET1, BRD4, PHKB CES2 2325/4885CES1 2001/4885MEN1 4792/4885
US-20250263370-A1 PYRROLES AND IMIDAZOLES AS BET PROTEIN INHIBITORS BET1, PHKB, BRD4 CES2 4265/4885CES1 3291/4885MEN1 4098/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.