Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11554821 | 0.87 | MMP2 (0.50) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11558589 | 0.87 | ALDH1A1 (0.47) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11554835 | 0.76 | ACLY (0.43) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11555047 | 0.74 | MMP2 (0.53) | ALDH1A1CA12CA9CA1CA2 | |
| SCHEMBL11555434 | 0.73 | CA1 (0.50) | KDM4EALDH1A1HPGDHSD17B10CA12 | |
| SCHEMBL11557285 | 0.73 | CA1 (0.52) | ALDH1A1KMT2ACA12CA9CA1 | |
| SCHEMBL11553460 | 0.73 | TSHR (0.46) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11553411 | 0.71 | CNR2 (0.40) | HSD17B10MAPK1CA1CA2MMP2 | |
| SCHEMBL11552685 | 0.71 | NR4A2 (0.46) | ALDH1A1HSD17B10KMT2APKMNPSR1 | |
| SCHEMBL11555575 | 0.71 | CYP2C19 (0.62) | TSHRALDH1A1HPGDHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156732-A | Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |