Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | DRD3 | P35462 | 3/20 | 0.63 |
| ▸ | HTR1A | P08908 | 3/20 | 0.62 |
| ▸ | HTR7 | P34969 | 2/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11628968 | 0.86 | DRD2 (0.58) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL11631256 | 0.83 | HTR1A (0.62) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL11631804 | 0.83 | L3MBTL1 (0.59) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL11628469 | 0.82 | L3MBTL1 (0.47) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL11634429 | 0.81 | L3MBTL1 (0.46) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL11632693 | 0.81 | DRD2 (0.88) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL11630691 | 0.80 | KDM4E (0.61) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL11632015 | 0.79 | HTR7 (0.60) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL11633309 | 0.79 | RAD52 (0.49) | DRD2HTR1AHTR7HTR2AHTR6 | |
| SCHEMBL11635081 | 0.79 | L3MBTL1 (0.56) | MAPTMEN1KMT2AALDH1A1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |