Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.46 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.46 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.46 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11634992 | 0.84 | L3MBTL1 (0.53) | L3MBTL1DRD2DRD3HTR7OPRL1 | |
| SCHEMBL11636284 | 0.82 | DRD2 (0.63) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL11808412 | 0.80 | DRD2 (0.66) | SLC6A1SLC6A12SLC6A11SLC6A13DRD2 | |
| SCHEMBL11634977 | 0.79 | L3MBTL1 (0.47) | L3MBTL1DRD2OPRM1OPRL1LMNA | |
| SCHEMBL11744846 | 0.78 | L3MBTL1 (0.51) | L3MBTL1DRD2HTR2AOPRM1OPRD1 | |
| SCHEMBL11629536 | 0.78 | SIGMAR1 (0.46) | L3MBTL1DRD2HTR7OPRL1LMNA | |
| SCHEMBL11629858 | 0.78 | L3MBTL1 (0.44) | L3MBTL1OPRM1OPRL1LMNARAD52 | |
| SCHEMBL11630716 | 0.78 | RAD52 (0.43) | L3MBTL1DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL11629977 | 0.77 | SIGMAR1 (0.46) | L3MBTL1DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL11630749 | 0.77 | L3MBTL1 (0.50) | L3MBTL1DRD2HTR2AOPRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |