Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.39 |
| ▸ | PTPRG | P23470 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11820018 | 0.89 | CA2 (0.53) | CA2CA4EPAS1PTPRGALDH1A1 | |
| SCHEMBL11817917 | 0.88 | PTPRG (0.47) | CA2CA4EPAS1PTPRGPTPRC | |
| SCHEMBL11817749 | 0.88 | PTPRG (0.44) | CA2CA4EPAS1PTPRGALDH1A1 | |
| SCHEMBL11814899 | 0.88 | PPARD (0.43) | CA2CA4EPAS1PTPRGCA12 | |
| SCHEMBL11818479 | 0.84 | CA2 (0.46) | CA2CA4EPAS1PTPRGALDH1A1 | |
| SCHEMBL11818557 | 0.83 | FKBP1A (0.47) | CA2CA4PTPRGALDH1A1PTPRZ1 | |
| SCHEMBL11838590 | 0.83 | LMNA (0.40) | CA2CA4EPAS1PTPRGALDH1A1 | |
| SCHEMBL11821552 | 0.81 | CA2 (0.42) | CA2CA4PTPRGALDH1A1 | |
| SCHEMBL11818248 | 0.81 | CA2 (0.43) | CA2CA4EPAS1PTPRGALDH1A1 | |
| SCHEMBL11821491 | 0.81 | MEN1 (0.45) | CA2CA4ALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3954994-A | Intermediates for preparing hipolipemic agents and method of lowering the blood lipid level in mammals with said agents | PFIZER INC. (US) | 1976-05-04 | — | — | US | disclosed |