Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Indigotindisulfonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.50 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.50 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 6/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 5/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indigotindisulfonate SCHEMBL29352151 | 1.00 | CA12 (0.50) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL40486 | 1.00 | CA12 (0.50) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL20775438 | 0.98 | CA12 (0.49) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL3206773 | 0.92 | CA12 (0.44) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL2300219 | 0.92 | CA12 (0.44) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL454611 | 0.85 | CA12 (0.69) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL4553415 | 0.84 | CA12 (0.38) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL4553414 | 0.84 | CA12 (0.38) | CA12CA1CA2CA9CASP3 | |
| Water SCHEMBL7085288 | 0.84 | CA12 (0.67) | CA12CA1CA2CA9CASP3 | |
| Potassium Ion SCHEMBL2867164 | 0.83 | CA12 (0.40) | CA12CA1CA2CA9CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3027 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12005421-B1 | Method of preparing adsorbent from sugarcane bagasse and polyolefin waste | King Faisal University (SA) | 2024-06-11 | — | — | US | claimed |
| EP-3956369-B1 | SENSOR BASED ON A POLYOLEFIN MATRIX AND A SENSING COMPOUND | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2024-05-22 | — | — | EP | claimed |
| US-20240156992-A1 | Ophthalmic Compositions, and Ocular Uses Thereof, of Indigo Carmine | ZEBRA BIOTECH PTY LTD (AU) | 2024-05-16 | — | — | US | claimed |
| US-11938462-B1 | Activated carbon flakes using palm fiber and polyethylene waste | King Faisal University (SA) | 2024-03-26 | — | — | US | claimed |
| EP-4331464-A1 | DECONTAMINATION AGENT VISUALIZING SHEET, DECONTAMINATION AGENT VISUALIZING PARTICLE, AND DECONTAMINATION AGENT VISUALIZING METHOD USING SAME, AND INFORMATION ACQUISITION SYSTEM | CANON KABUSHIKI KAISHA (JP) | 2024-03-06 | — | — | EP | claimed |
| US-20240050614-A1 | DISINFECTANT VISUALIZATION SHEET, DISINFECTANT VISUALIZATION PARTICLE, DISINFECTANT VISUALIZATION METHOD USING SHEET OR PARTICLE, AND INFORMATION ACQUISITION SYSTEM | CANON KABUSHIKI KAISHA (JP) | 2024-02-15 | — | — | US | claimed |
| US-11896952-B1 | Adsorbent using biowaste and plastic waste for wastewater treatment | King Faisal University (SA) | 2024-02-13 | — | — | US | claimed |
| US-11896950-B1 | Activated carbon composite flakes using olive stone-polyethylene waste | King Faisal University (SA) | 2024-02-13 | — | — | US | claimed |
| WO-2024010829-A1 | PHOTO-CATALYTIC ANTIMICROBIAL PACKAGING FILMS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2024-01-11 | — | — | WO | claimed |
| US-20240011099-A1 | STAINED BIOLOGICAL SPECIMENS INCLUDING ONE OR MORE BIOMARKERS LABELED WITH ONE OR MORE DETECTABLE MOIETIES | VENTANA MED SYST INC (US) | 2024-01-11 | — | — | US | claimed |
| WO-1994023646-A1 | STABILIZATION OF VOLTAGE SENSITIVE DYES | MALLINCKRODT MEDICAL, INC. (US) | 1994-10-27 | — | — | WO | claimed |
| EP-0618949-A1 | IONIC DYE-BASED ELECTRORHEOLOGICAL MATERIALS | LORD CORPORATION (US) | 1994-10-12 | — | — | EP | claimed |
| EP-0618949-A4 | IONIC DYE-BASED ELECTRORHEOLOGICAL MATERIALS. | LORD CORP (US) | 1994-07-07 | — | — | EP | claimed |
| US-5306438-A | Dielectric hydrophobic liquid carrier fluid with anionic dye particles; quick response | LORD CORPORATION (US) | 1994-04-26 | — | — | US | claimed |
| US-5300293-A | Mixture of antigrowth agent and dextrin | SUMITOMO CHEMICAL CO., LTD. (JP) | 1994-04-05 | — | — | US | claimed |
| US-5250385-A | Photosensitivity, storage stability | FUJI PHOTO FILM CO., LTD. (JP) | 1993-10-05 | — | — | US | claimed |
| WO-1993019143-A1 | COLORANT-CONTAINING ELECTRORHEOLOGICAL MATERIALS | LORD CORPORATION (US) | 1993-09-30 | — | — | WO | claimed |
| WO-1993012192-A1 | IONIC DYE-BASED ELECTRORHEOLOGICAL MATERIALS | LORD CORPORATION (US) | 1993-06-24 | — | — | WO | claimed |
| US-5096710-A | Cockroaches, juvenile hormone or chitin synthesis inhibitor, dextrin, plant oil | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-03-17 | — | — | US | claimed |
| US-4834977-A | Poison bait for control of noxious insects | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-05-30 | — | — | US | claimed |