Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Indigotindisulfonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.49 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.49 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 6/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP9 | P55211 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 5/20 | 0.37 |
| ▸ | CES1 | P23141 | 3/20 | 0.37 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indigotindisulfonate SCHEMBL29352151 | 0.98 | CA12 (0.50) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL40486 | 0.98 | CA12 (0.50) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL118376 | 0.98 | CA12 (0.50) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL3206773 | 0.90 | CA12 (0.44) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL2300219 | 0.90 | CA12 (0.44) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL454611 | 0.84 | CA12 (0.69) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL4553414 | 0.83 | CA12 (0.38) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL4553415 | 0.83 | CA12 (0.38) | CA12CA1CA2CA9CASP3 | |
| Indigotindisulfonate SCHEMBL9107944 | 0.82 | CA12 (0.49) | CA12CA1CA2CA9CASP3 | |
| Water SCHEMBL7085288 | 0.82 | CA12 (0.67) | CA12CA1CA2CA9CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11192860-B2 | Co-crystal of an orally available HIF prolyl hydroxylase inhibitor | SANDOZ AG (CH) | 2021-12-07 | — | — | US | disclosed |
| US-20200262792-A1 | Co-Crystal of an Orally Available Hif Prolyl Hydroxylase Inhibitor | SANDOZ AG (CH) | 2020-08-20 | — | — | US | disclosed |
| EP-3679017-A1 | CO-CRYSTAL OF AN ORALLY AVAILABLE HIF PROLYL HYDROXYLASE INHIBITOR | Sandoz AG (CH) | 2020-07-15 | — | — | EP | disclosed |
| WO-2019042641-A1 | CO-CRYSTAL OF AN ORALLY AVAILABLE HIF PROLYL HYDROXYLASE INHIBITOR | SANDOZ AG (CH) | 2019-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200262792-A1 | Co-Crystal of an Orally Available Hif Prolyl Hydroxylase Inhibitor | HIF1AN, EGLN3, EGLN2 | CA12 1694/4885CA1 1407/4885CA2 194/4885 |
| US-11192860-B2 | Co-crystal of an orally available HIF prolyl hydroxylase inhibitor | HIF1AN, EGLN3, EGLN2 | CA12 1694/4885CA1 1407/4885CA2 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.